Chronopharmacology of trichlormethiazide in rats.
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概要
- 論文の詳細を見る
Trichlormethiazide was given orally at 1200 hrs or 2400 hrs to rats. Its diuretic effects were greater at 1200 hrs than at 2400 hrs. There were significant correlations between urinary trichlormethiazide and its effects in both trials. The regression lines of two trials did differ. These findings indicate that the effects of trichlormethiazide vary with its administration time. Time-dependent variations in urinary trichlormethiazide and susceptibility to the agent might be involved in this phenomenon.
- 公益社団法人 日本薬理学会の論文
著者
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Ohira Hiroshi
Department Of Cardiology Edogawa Hospital
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Shiga Tsuyoshi
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Fujimura Akio
Department of Clinical Pharmacology, Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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