Influence of .ALPHA.-Receptor Blockade on the Time-Dependent Change in the Effect of Furosemide.
スポンサーリンク
概要
- 論文の詳細を見る
Influence of α-receptor blockade on the time-dependent change in the effect of furosemide (a loop diuretic agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an α<SUB>1</SUB>-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the α<SUB>1</SUB>-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.
- 公益社団法人 日本薬理学会の論文
著者
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Shiga Tsuyoshi
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Sudoh Toshiaki
Department Of Clinical Pharmacology Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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