Chronopharmacology of Probucol in Mice.
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概要
- 論文の詳細を見る
Mice were maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Probucol was given orally to these animals once daily at 10 a.m. or 10 p.m. for 7 days. Blood samples for serum cholesterol were obtained at 24 hours after the final dosage. Blood samples for plasma probucol were obtained just before and at 3, 6, 12, 24, 48, 72, 96 and 120 hours after the final dosage. The cholesterol lowering effect of the agent at 10 p.m. was greater than that at 10 a.m. Plasma probucol concentrations of the two trials did not differ at any observation point. These data suggest that the effect of probucol varies with its time of administration. This might not be caused by a time-dependent change in plasma probucol concentration.
- 公益社団法人 日本薬理学会の論文
著者
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Ohira Hiroshi
Department Of Cardiology Edogawa Hospital
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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EBIHARA Akio
Department of Clinical Pharmacology, Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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Ohira Hiroshi
Department of Clinical Pharmacology, Jichi Medical School
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