Clinical Pharmacology of a New Antithrombotic Agent, Ticlo
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概要
- 論文の詳細を見る
A new antithrombotic agent, ticlopidine was administered to 6 healthy volunteers to investigate its effects on platelet function and blood coagulation as well as its safety.No problem was noticed in the safety of the drug when 500 mg was orally administered every 12 hours for 3 days. Blood concentration of the drug reached the peak level 2 hours after administration and it was not detected in blood 8 hours after administration. It was observed that ticlopidine exerted longlasting suppressive effect on platelet aggregation and adhesiveness, but it did not show any effect on the blood clotting and fibrinolysis systems.
- 一般社団法人 日本臨床薬理学会の論文
著者
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Suzuki Tadao
Research & Development Center, UNlTIKA Ltd.
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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SUZUKI Tadao
Research Institute, Daiichi Seiyaku Co., Ltd.
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AOKI Nobuo
Institute of Hematology, Jichi Medical School
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YOSHIDA Nobuhiko
Institute of Hematology, Jichi Medical School
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SANO Mitsushi
Research Institute, Daiichi Seiyaku Co., Ltd.
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MATSUBAYASHI Kyuichi
Research Institute, Daiichi Seiyaku Co., Ltd.
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