Effect of Withdrawal of Dietary Sodium in Hypertensive and Normotensive Rats
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概要
- 論文の詳細を見る
The effect of withdrawing dietary sodium was determined in 10 rats with marked hypertension induced by ligation of a branch of the renal artery and contralateral nephrectomy and in 10 normal control animals. No significant change occurred in the systolic blood pressure of either group of animals during 5 days of sodium withdrawal. Throughout the period of observation, the urinary output was greater in the hypertensive than in the normotensive group. Reduction of urinary output and water intake was observed in both groups during sodium depletion. The reduction in the urinary excretion of sodium was greater in the hypertensives than in the normal animals for several days after sodium was withdrawn. Hypertensive rats, accordingly, retain sodium more efficiently than do normotensives after sodium withdrawal.
- International Heart Journal刊行会の論文
著者
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Ebihara Akio
Department Of Clinical Pharmacology Medical College Of Oita
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MARTZ B.L.
Department of Experimental Medicine, University of Texas Southwestern Medical School
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GROLLMAN Arthur
Lilly Laboratory for Clinical Research, Marion County General Hospital
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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EBIHARA Akio
Department of Experimental Medicine, University of Texas Southwestern Medical School
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