Chronopharmacology of the New Uricosuric Diuretic S-8666 in Rats.
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概要
- 論文の詳細を見る
A new loop diuretic with uricosuric activity, 6, 7-dichloro-5-(N, N-dimethylsulfamoyl)-2, 3-dihydro-2-benzofuran carboxylic acid (S-8666), was given orally at 12:00 a.m. or 12:00 p.m. in rats. The diuretic of S-8666 and the urinary excretions of the drug and its active metabolite S-8680 (N-demethyl S-8666) were greater at 12:00 a.m. than at 12:00 p.m.. Thus, the present study indicates that the diuretic effects of S-8666 varies with its administration time. Time-dependent variations in the amount of urinary excretions of S-8666 and S-8680 might be involved in the mechanisms for this phenomenon.
- 公益社団法人 日本薬理学会の論文
著者
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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