Influence of Chronic Lithium Treatment on Urinary Amount of Furosemide in Rats.
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概要
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The present study was undertaken to examine whether the urinary amount of furosemide is influenced by chronic lithium treatment. LiCl at 2 mEq/kg/day in 1 ml vehicle (5% glucose solution) or 1 ml of vehicle alone was injected intraperitoneally for 8 days into Wistar rats. On day 8, 30 mg/kg of furosemide in 3% body weight of 1 % NaCl was given orally, and urine was collected for 6 hr after dosage. The urinary amount of furosemide in the Li-treated rats was significantly lower than that in the control animals [Li group (n = 12): 514 ± 75 (mean ± S.E.) vs. control group (n = 12): 916 ± 85 μg/kg/6 hr, P < 0.01]. This finding indicates that pharmacokinetic alterations of furosemide might occur during chronic treatment with lithium.
- 公益社団法人 日本薬理学会の論文
著者
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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