Influence of Repeated Administration of Lithium on Urinary Excretion of Prostaglandins in Rats.
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概要
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The present study was undertaken to examine whether urinary excretions of prostaglandins increase by repeated administration of a non-toxic dose of lithium. Our previous study demonstrated that 2 mEq/kg/day of lithium chloride (LiCl) is not a toxic dose; and therefore, this dose of LiCl in 1 ml vehicle (5% glucose solution) or 1 ml of vehicle alone was injected intraperitoneally for 7 days into Wistar rats. On day 7, 3% body weight of 1% NaCl solution was given orally; and urine for the determination of PGE<SUB>2</SUB> and 6-keto-PGF<SUB>1α</SUB>, a metabolite of PGI<SUB>2</SUB>, was collected for 6 hr after dosage. Thereafter, blood samples for measuring plasma renin activity (PRA) were obtained. The urinary amounts of PGE<SUB>2</SUB> and 6-keto-PGF<SUB>1α</SUB> in the Litreated rats were significantly greater than those in the control animals. The values of PRA did not significantly differ between the two groups of rats. These findings indicate that the production of prostaglandins, including those of PGE<SUB>2</SUB> and PGI<SUB>2</SUB>, are enhanced during repeated administration of a non-toxic dose of lithium. The enhanced production of prostaglandins might not be mediated through the activated renin-angiotensin system.
- 公益社団法人 日本薬理学会の論文
著者
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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