Effect of Amezinium Metilsulfate on the Finger Skin Vasoconstrictor Response to Cold Stimulation and Venoconstrictor Response to Noradrenaline
スポンサーリンク
概要
- 論文の詳細を見る
Orthostatic hypotension can be caused by an inadequate vasoconstrictor response. The effects of amezinium on vasoconstrictor response to sympathetic stimulation and to exogenous noradrenaline were investigated and compared with those of midodrine. In 8 healthy men, the following experiments were performed after a single oral dose of 10 mg of amezinium, 2 mg of midodrine or a placebo. First, finger-tip blood flow(FTBF)was recorded using a laser Doppler flowmeter before and during the contralateral hand cooling and a reduction ratio of FTBF was calculated as an index of the vasoconstrictor response. Second, dose-response curves to increasing doses(1-512ng/min)of noradrenaline infused locally to the dorsal hand vein were determined using a linear variable differential transformer. The reduction ratio of FTBF was significantly increased(p<0.05)by amezimium[placebo, 75.9±9.8(mean±SD)% ; amezinium, 85.1±7.9% ; midodrine, 78.1±9.3%]. The infusion rate of noradrenaline producing a half-maximum venoconstriction was significantly decreased(p<0.05)by amezinium(placebo, 40.6±33.9ng/min ; amezinium, 21.0±21.3ng/min ; midodrine, 33.2±31.5ng/min). These findings indicate that amezinium increases the vasoconstrictor response to sympathetic stimulation and to noradrenaline in normal subjects, and this mechanism might contribute to the improvement by amezinium of the symptoms of orthostatic hypotension.
- 1998-10-20
著者
-
Fujimura A
Jichi Medical School Tochigi Jpn
-
Fujimura Akio
自治医科大学 薬理学
-
Ohashi Kyoichi
Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine
-
Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
-
Fujimura Akio
Institute Of Space And Astronautical Sciences
-
OHMORI Masami
Department of Clinical Pharmacology, Jichi Medical School
-
HARADA Kazuhiro
Department of Clinical Pharmacology, Jichi Medical School
-
HARADA Kazuhiro
Kasaoka Daiichi Hospital
-
Fujimura Akio
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
-
Ohmori Masami
Department Of Clinical Pharmacology Jichi Medical School
-
Ohashi Kyoichi
Department Of Clinical Pharmacology
-
Ohashi Kyoichi
Department Of Clinical Pharmacology Hamamatsu University School Of Medicine
-
Harada Kazuhiro
Department Of Clinical Pharmacology Jichi Medical School
-
HARADA Kazuhiro
Department of Cardiology,Chubu Rosai Hospital
関連論文
- Blood Pressure Lowering Effect of a New Transdermal Clonidine, M-5041T, during a Resting Period in Subjects with Essential Hypertension
- ROLE OF AUTONOMIC NERVOUS BLOOD PRESSURE VARIABILITY : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
- Excessive nitric oxide production and cardiac dysfunction in patients with chronic renal failure
- 4 Inhibition of Type-5 Phosphodiesterase : Promising Therapy for Pulmonary Hypertension(Which drug is useful for the treatment of pulmonary hypertension?,Topic 4 (TP4) (M),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-243 Regenerated Endothelium Produces not Vasodilative but Vasoconstrictive Prostanoid(s) via Cyclooxygenase-dependent Pathway(Chronic coronary heart disease/Remodeling(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japane
- Inhibition of Type 5 Phosphodiesterase : Promising Therapy for Pulmonary Hypertension
- A potential role of sildenafil in the management of pulmonary hypertension
- A novel nonpeptide bradykinin receptor agonist in the regulation of endothelial calcium signaling and coronary artery tone
- Interaction between Amlodipine and Simvastatin in Patients with Hypercholesterolemia and Hypertension
- Failure of Probucol to Prolong Survival in Salt-Loaded Stroke-Prone Spontaneously Hypertensive Rats
- Effects of Renin-Angiotensin System Blockade and Dietary Salt Intake on Left Ventricular Hypertrophy in Dahl Salt-Sensitive Rats
- Clinical Pharmacology of the New Thromboxane A_2 Receptor Antagonist, S-1452 : A Repeated Administration Study
- Genetic effects on circadian rhythm of heart rate in twins reared apart
- EFFECTS OF VERAPAMIL ON DIGOXIN KINETICS AND INTRAERYTHROCYTE DIGOXIN CONCENTRATION : Heart Failure, Cardiovascular Drugs (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- Different Effects of Imidapril and Enalapril on Aminopeptidase P Activity in the Mouse Trachea
- Effect of Intraperitoneal Neutrophils Induced by OK432 on Malignant Ascites
- A Comparative Pharmacology Study Between the Intracolonic and Oral Routes of 5-FU Administration in a Colon Cancer-Bearing Yoshida Sarcoma Rat Model
- Sustained Plasma Fibrinogen Elevation in Subtotal Nephrectomized Rats : Effect of Cilazapril, an Angiotensin-Converting Enzyme Inhibitor
- Pravastatin Prevents Arrhythmias Induced by Coronary Artery Ischemia/Reperfusion in Anesthetized Normocholesterolemic Rats
- Vasoconstricting Effect of Angiotensin II in Human Hand Veins : Influence of Aging, Diabetes Mellitus and Hypertension
- Frequency of Prescriptions that could Cause Harmful Drug Interactions and Usefulness of Providing such Information
- Dosing Time-Dependent Effect of Trandolapril on the Prevention of Cardiac Hypertrophy in Rats With Aortic Banding
- Shoulder Stiffness: A Common Adverse Effect of HMG-CoA Reductase Inhibitors in Women?
- Effect of Prolonged Nitric Oxide Synthesis Inhibition on Plasma Fibrinogen Concentration in Rats
- Influence of Dosing Time of Enalapril on the Daily Variation of Pulmonary Function : A Preliminary Study
- RAT ORGAN TRANSPLANTATION USING CUFF ANASTOMOSIS
- Amelioration of Enalapril-Induced Dry Cough by Changing Dosing Time from Morning to Evening : A Preliminary Trial
- A Comparison of the Antagonistic Activities of Tamsulosin and Terazosin Against Human Vascular α_1-Adrenoceptors
- Changes in fecal fat excretion from allo-intestine transplanted rats after discontinuance of immunosuppressive agents
- Alleviation of Nephropathy Induced by Immunosuppressive Agents
- Levothyroxine-Induced Liver Dysfunction in a Primary Hypothyroid Patient
- Effect of Amezinium Metilsulfate on the Finger Skin Vasoconstrictor Response to Cold Stimulation and Venoconstrictor Response to Noradrenaline
- Timing of Lymphocyte Transfusion and Portal Clamping for the Development of Lethal Graft-versus-Host Disease in the Rat
- Endoscopic findings in transplanted allo-intestine of rats after discontinuance of immunosuppressive agent
- Role of Bradykinin in the Reduction of Left Ventricular Hypertrophy Induced by Angiotensin-Converting Enzyme Inhibitors in Spontaneously Hypertensive Rats
- Pharmacokinetics of a New Thromboxane A_2 Receptor Antagonist, S-1452,and Its Effect on Platelet Aggregation in the Elderly
- Effect of Probenecid and Ranitidine on Urinary Excretion of Lomefloxacin in Rats
- P486 Effect of amezinium and midodrine on vasoconstrictor response to sympathetic stimulation.
- Long-Term Effects of Doxazosin, an Alpha_1-Blocker, on Serum Lipids in Hypertensive Patients
- PLANNED EXPLOSION SEISMIC EXPERIMENTS IN EAST QUEEN MAUD LAND USING A PENETRATOR
- Generation of Large Volume Hydrostatic Pressure to 8 GPa for Ultrasonic Studies
- Fractal dimensions of fracture surfaces of rock fragments
- Preferred orientation of phyllosilicates in Yamato-74642 and -74662, in relation to deformation of C2 chondrites
- A Comparative Pharmacology Study Between the Intracolonic and Oral Routes of 5-FU Administration in a Colon Cancer-Bearing Yoshida Sarcoma Rat Model
- Improvement in the Histopathology of Hearts from Cardiomyopathic BIO TO-2 Hamsters Following Long-Term Administration of Amlodipine and Cilnidipine
- Effects of Astemizole on Ventricular Activation Delay and RT Intervals in a Canine Myocardial Infarction Model
- A VARIOUS METHODS FOR EVALUATING ANTIARRHYTHMIC DRUG EFFECT USING VENTRICULAR ARRHYTHMIA REDUCTION ON AMBULATORY ECG : Arrhythmia : 46th Annual Scientific Meeting, Japanese Circulation Society
- -471- THE EFFECT OF DILTIAZEM ON PLASMA NIFEDIPINE CONCENTRATION IN HUMAN VOLUNTEERS
- Benzbromarone Pharmacokinetics and Pharmacodynamics in Different Cytochrome P450 2C9 Genotypes
- Characteristics of Clinical Trials Conducted in Japan under the New GCP Guideline : Analysis of PMDA Audit Reports
- Attitudes of local people towards conservation and Gunung Halimun National Park in West Java, Indonesia
- Dependency of local people on the forests of Gunung Halimun National Park, West Java, Indonesia
- The paradoxical adverse effect of verapamil for treating clinical paroxysmal supraventricular tachycardia.
- Chronopharmacokinetic Study of a New Immunosuppressive Agent, FK 506, in Mice.
- Frequency of Prescriptions that could Cause Harmful Drug Interactions and Usefulness of Providing such Information.
- Beneficial effects of combined nifedipine and diltiazem for stable angina.
- Chronopharmacology of Trichlormethiazide in Rats: (III). Influence on Serum Triglyceride and Glucose.
- Influence of Chronic Lithium Treatment on Urinary Amount of Furosemide in Rats.
- Diurnal Variation in the Diuretic Effects of Nitrendipine in Saline Loaded Rats.
- Comparison of Class II and Class III Activity of dl-Sotalol in Healthy Volunteers.
- Chronopharmacology of Probucol in Mice.
- Influence of Adrenalectomy on Chronopharmacological Phenomenon of Furosemide in Rats.
- Chronopharmacology of the New Uricosuric Diuretic S-8666 in Rats:(II)Examination in Aged Rats.
- Daily Variation in the Effects of Furosemide in Rats.
- Chronopharmacology of trichlormethiazide in rats.
- Influence of .ALPHA.-Receptor Blockade on the Time-Dependent Change in the Effect of Furosemide.
- Chronopharmacology of the New Uricosuric Diuretic S-8666 in Rats.
- Administration Time-Dependent Change in the Effect of Spironolactone in Rats.
- Influence of Repeated Administration of Lithium on Urinary Excretion of Prostaglandins in Rats.
- Influence of captopril on the diuretic effects of furosemide in healthy subjects; A preliminary study.
- Chronopharmacology of Furosemide in Rats with Amikacin-Induced Acute Renal Damage.
- Prognostic impact of concurrence of metabolic syndrome and chronic kidney disease in patients undergoing coronary intervention:Involvement of coronary plaque composition