The Mechanism of Low-renin Hypertension : Aldosterone Response to Sodium Restriction and Upright Posture, Angiotensin II, ACTH and Potassium in Patients with Hypertension

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概要

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• Plasma renin activity and aldosterone were measured simultaneously in 67 out-patients with essential hypertension. High aldosterone was more often in patients with high renin, and low levels of aldosterone were usual in those with low or normal renin. In order to study the mechanism by which aldosterone and renin activity are suppressed in low-renin hypertension, 25 patients (13 normal-renin hypertensives, 10 low renin patients including 4 non-responders and two DOC excess hypertensives) were investigated as inpatients. Plasma renin activity, aldosterone and cortisol were determined by the following stimulations with 3 days of sodium restriction and 2 hours of upright posture, angiotensin II infusion (at a dose which increased 20mmHg of diastolic blood pressure), ACTH administration (rapid i.m. injection of 0.25 mg of alpha 1-24 preparation) and potassium infusion (30meq of potassium i.v.). Responses of aldosterone in normal-renin hypertensives to all stimulations were 3-5 fold increases from base line values. Low renin hypertensives except two of four non-responders showed the responses similar to those in normal-renin patients. The responses of two of the non-responders were similar to those in DOC excess hypertensives who showed reduced responses of aldosterone to some of these stimulations. Thus, it seems that low-renin hypertension is a clinical entity caused by a variety of mechanisms, and the mechanism by which low-renin hypertension is induced is not explained by one factor such as an unknown mineralocorticoid.

• 社団法人日本循環器学会の論文
• 1976-09-20

著者

• SARUTA Takao

  Department of Internal Medicine, School of Medicine, Keio University

• Saito Ikuo

  Department Of Internal Medicineicine Keio University School Of Medicine

• Saruta Takao

  Department Of Clinical Pharmacology Jichi Medical School

• NAKAMURA Ryuichi

  Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University

• KONDO KAZUOKI

  Departments of Internal Medicine,School of Medicine, Keio University

• MATSUKI SHUN

  Departments of Internal Medicine,School of Medicine, Keio University

• Matsuki Shun

  Department Of Internal Medicineicine Keio University School Of Medicine

• Matsuki Shun

  Department Of Internal Medicine Keio University

• Kondo Kazuoki

  Department Of Clinical Pharmacology Jichi Medical Schcol

• Saito Ikuo

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• MISUMI JIRO

  Department of lnternal Medicine, Endocrine Section, Keio University, School of Medicine

• Kondo K

  Department Of Internal Medicine School Of Medicine Keio University

• Kondo Kazuoki

  Departments Of Internal Medicine School Of Medicine Keio University

• Matuki Susumu

  Dept. Of Intern. Med. School Of Med. Keio University Tokyo

• Misumi Jiro

  Department Of Lnternal Medicine Endocrine Section Keio University School Of Medicine

• Nakamura Ryuichi

  Department Of Internal Medicine School Of Medicine Keio University

• Nakamura Ryuichi

  Department Of Chemical Engineering Faculty Of Engineering Tokyo Institute Of Technology

• Nakamura Ryuichi

  Department Of Internal Medicine Keio University School Of Medicine

• MISUMI Jiro

  Department of Internal Medicine, Keio University School of Medicine

• MATSUKI SHUN

  Department of Internal Medicine , Keio University

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