Central Hypertensive Actions of Angiotensin I, II and III in Conscious Rats
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概要
- 論文の詳細を見る
The effects of intracerebroventricular administrations of three natural angiotensins, angiotensin I (ANG I 3.8×10<SUP>-11</SUP>-9.4×10<SUP>-10</SUP>mol/kg body weight), II (9.6×10<SUP>-12</SUP>-2.4×10<SUP>-10</SUP>mol/kg body weight) and III (2.7×10<SUP>-10</SUP>-2.5×10<SUP>-9</SUP>mol/kg body weight) on systemic blood pressure were investigated in conscious rats. Angiotensin II (ANG II), ANG I and angiotensin III (ANG III), increased blood pressure in a doserelated manner. The order of potency of angiotensins was ANG II>ANG I>ANG III. The intraventricular administration of a converting enzyme inhibitor (SQ 14225, 6.9×10<SUP>-8</SUP>mol/kg) abolished the central effect of ANG I, while an angiotensin II analogue ([Sar<SUP>1</SUP>-Ala<SUP>8</SUP>] ANG II, 1.1×10<SUP>-8</SUP>mol/kg) administered intraventricularly inhibited the central pressor effects of these three angiotensins. These results suggest that ANG II is a main mediator of the renin-angiotensin system in the central nervous system.
- 社団法人 日本内分泌学会の論文
著者
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SARUTA Takao
Department of Internal Medicine, School of Medicine, Keio University
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YASUI Toshiyuki
Department of Obstetrics and Gynecology, Tokushima University School of Medicine
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Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
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NAKAMURA Ryuichi
Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University
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KONDO KAZUOKI
Departments of Internal Medicine,School of Medicine, Keio University
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Kondo Kazuoki
Department Of Clinical Pharmacology Jichi Medical Schcol
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Yasui Toshiyuki
Department Of Electronic Science And Engineering Kyoto University
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OKUNO TETSUJI
Department of Internal Medicine, School of Medicine, Keio University
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EGUCHI TOYOHISA
Department of Internal Medicine, School of Medicine, Keio University
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Okuno Tetsuji
Department Of Internal Medicine School Of Medicine Keio University
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Kondo K
Department Of Internal Medicine School Of Medicine Keio University
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Kondo Kazuoki
Departments Of Internal Medicine School Of Medicine Keio University
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Eguchi Toyohisa
Department Of Internal Medicine School Of Medicine Keio University
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Nakamura Ryuichi
Department Of Internal Medicine School Of Medicine Keio University
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Nakamura Ryuichi
Department Of Chemical Engineering Faculty Of Engineering Tokyo Institute Of Technology
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Okuno Tetsuji
Department Of Internal Medicine Nippon Kokan Fukuyama Hospital
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