Synthesis and function of sialic acid-conjugated cholesterols as ganglioside analogs: their reconstitution to liposomes and interaction with rat lymphocytes
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概要
- 論文の詳細を見る
Sialic acid-conjugated cholesterols (SC) with different spacer lengths were synthesized as ganglioside analogs. The interaction of SC (12mol%)-containing liposomes with rat lymphocyte cells was investigated by monitoring increases in the intracellular calcium signal under a confocal fluorescence microscopy. Cells were stimulated strongly in the presence of SC-containing liposomes, while free SC not reconstituted to liposomes did not significantly stimulate the cells. The reconstitution of sialolipids to liposomes play a crucial role in the stimulation of cells. The efficiency of SC-containing liposomes was comparable to that of the naturally occurring gangliosides, GT1b-containing liposomes.
著者
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Akiyoshi Kazunari
Department Of Organic Material Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental
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Kato Eiichi
Department Of Internal Medicine School Of Medicine Keio University
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SUNAMOTO JUNZO
Department of Applied Chemistry and Biotechnology, Niihama National College of Technology
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AKIYOSHI Kazunari
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
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TAGUCHI Atushi
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
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SAKASHITA Shin-ichi
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
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