Liposomal membranes. IV. Fusion of liposomal membranes induced by several lipophilic agents.
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概要
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It was found that several lipophilic agents, such as <I>cis</I>-, <I>trans</I>-ethyl decaprenoate and their structural analogues, significantly induce the liposome-liposome fusion when incubated together a set of two different liposomes, the <I>A</I>-liposome containing a marker and the <I>B</I>-liposome involving a lipophilic agent. The rate and extent of fusion were followed spectrophotometrically by monitoring the leakage of an amphiphilic marker, Bromothymol Blue, from the fused liposomes. Fusion was also visualized directly by electronmicrographic technique. When only <I>A</I>-liposome was incubated or when a blank liposome containing no lipophilic agents was added to the <I>A</I>-liposome after the preincubation, neither the fusion nor the marker release was observed at least in periods of several hours. Also, neither fusion nor the marker release was observed when either <I>A</I>- or <I>B</I>liposome or both were multicompart-ment liposome. Removing cholesterol from liposome significantly depressed the fusion. The effect of cholesterol was more prominent on the <I>A</I>-liposome side. <I>trans</I>-Ethyl decaprenoate was more effective about three-fold to induce the fusion than the <I>cis</I>-isomer. Interestingly, the effect was parallel to the antihypertensive activity of the agent.
- 公益社団法人 日本化学会の論文
著者
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SUNAMOTO JUNZO
Department of Applied Chemistry and Biotechnology, Niihama National College of Technology
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Murase Hiroki
Department of Industrial Chemistry, Faculty of Engineering, Nagasaki University
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Hamada Tomiko
Department of Industrial Chemistry, Faculty of Engineering, Nagasaki University
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