Poly(MPC-co-BMA) Coating Reduces the Adhesion of Candida albicans to Poly(Methyl Methacrylate) Surfaces

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概要

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• Purpose: The aim of the present study was to develop a new and simple method using PMB to prevent plaque colonization on denture surfaces.Methods: PMB polymerized with MPC polymer and BMA was prepared as a coating material. Water-insoluble PMB composed of 30 mol% MPC units (PMB30), water-soluble PMB composed of 80 mol% MPC units (PMB80) and clear PMMA disks were prepared. The PMMA disks were dip-coated in 0.5 wt% PMB30 solution or 0.5 wt% PMB80 solution. To examine the PMB coatings durability, the PMB-coated disks were immersed in distilled water. The PMB elution ratio was measured using a phosphorus analysis. To evaluate the effect of the PMB coating on Candida albicans (C. albicance) adhesion, PMB-coated and uncoated disks were cultured in a solution containing C. albicans for 48 hours. Half of the disks in each group were not washed, and the remaining disks were washed with distilled water to examine the effect of washing. All the PMMA disks were observed and photographed, and the resulting images were analyzed using imaging analysis software.Results: In the first 48 hours, approximate 14 % of the PMB30-coating and 12 % of the PMB80-coating were eluted into the distilled water. The adhesion of C. albicans to the PMB30-coated or the PMB80-coated PMMA disks was significantly reduced in both the washed and unwashed groups, compared with the uncoated control disks.Conclusion: PMB coating prevents the adhesion of C. albicans to PMMA.

• 日本補綴歯科学会の論文
• 2006-01-01

著者

• YAMAMOTO Naoki

  Department of Microbiology, Tokyo Medical and Dental University School of Medicine

• Yamamoto Naoki

  Department Of Bioregulation Research Nagoya City University Medical School

• AKIYOSHI Kazunari

  Department of Synthetic Chemistry & Biologocal Chemistry, Graduate School of Engineering, Kyoto Univ

• Mukohyama Hitoshi

  Department of Maxillofacial Prosthetics, Graduate School, Tokyo Medical and Dental University, Tokyo

• Taniguchi Hisashi

  Department of Maxillofacial Prosthetics, Graduate School, Tokyo Medical and Dental University, Tokyo

• IWASAKI Yasuhiko

  Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineerin

• Akiyoshi Kazunari

  Department Of Organic Material Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental

• Akiyoshi Kazunari

  Department Of Organic Materials Institute Of Biomaterials And Bioengineering Tokyo Medical And Denta

• Iwasaki Yuko

  Department Of Biology Faculty Of Science Yamagata University

• Mukohyama Hitoshi

  Department Of Maxillofacial Prosthetics Graduate School

• HATSUNO Kunito

  Department of Maxillofacial Prosthetics, Graduate School, Tokyo Medical and Dental University

• HORIUCHI Sankichi

  Department of Molecular Virology, Bio-Response, Graduate School, Tokyo Medical and Dental University

• Hatsuno Kunito

  Department Of Maxillofacial Prosthetics Graduate School Tokyo Medical And Dental University

• Taniguchi Hisashi

  Department Of Maxillofacial Prosthetics Graduate School

• Iwasaki Yasuhiko

  Department Of Biology Faculty Of Science Yamagata University

• Horiuchi Sankichi

  Department Of Molecular Virology Bio-response Graduate School Tokyo Medical And Dental University

• Horiuchi Sankichi

  Department Of Microbiology Faculty Of Medicine Tokyo Medical And Dental University

• Yamamoto Naoki

  Department Of Bioinformatics Faculty Of Engineering Soka University

• Yamamoto Naoki

  Department Of Molecular Virology Bio-response Graduate School Tokyo Medical And Dental University

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