SYNTHESIS OF SOME PEPTIDES CORRESPONDING TO THE ACTIVE REGION OF RANTES FOR CHEMOTAXIS AND EVALUATION OF THEIR ANTI-HUMAN IMMUNODEFICIENCY VIRUS-1 ACTIVITY

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概要

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• Five peptides corresponding to the amino-terminal sequence of RANTES (regulated upon activation, normal T-cell expressed and sereted), which is known to be the critical region for chemotaxis, were synthesized, and their anti-human immunodeficiency virus (HIV)-1 activity was examined to obtain a lead compound useful for the development of chemokine receptor-directed anti-HIV-1 drugs. A decapeptide corresponding to positions 1-10 [Ac-(^<10>Ala-RANTES 1-10)-NH_2] showed significant anti-HIV-1 activity. Ac-(^<10>Ala, ^<11>Ala-RANTES 5-14)-NH_2 was also active, but less potent than the former. Other peptides corresponding to the positions 6-14,7-14,and 8-14 did not show anti-HIV-1 activity. These results indicate that the sequence 1-10 of RANTES is important for the anti-HIV-1 effect.

• 公益社団法人日本薬学会の論文
• 1997-12-15

著者

• Nishiyama Yasuhiro

  Department of Cardiology, Kurume University Medical Center

• MURAKAMI Tsutomu

  Department of Microbiology, Tokyo Medical and Dental University School of Medicine

• YAMAMOTO Naoki

  Department of Microbiology, Tokyo Medical and Dental University School of Medicine

• Yamamoto Naoki

  Department Of Bioregulation Research Nagoya City University Medical School

• Murakami Tsutomu

  Department Of Microbiology Tokyo Medical And Dental University School Of Medicine

• Murakami Tsutomu

  Department Of Aeronautics And Astronautics Kyushu University

• KURITA Keisuke

  Department of Industrial Chemistry, Faculty of Engineering, Seikei University

• Kurita Keisuke

  Department Of Applied Chemistry Faculty Of Engineering Seikei University

• Kurita Keisuke

  Department Of Industrial Chemistry Faculty Of Engineering Seikei University

• Kurita Keisuke

  Department Of Materials And Life Science Faculty Of Science And Technology Seikei University

• Nishiyama Yasuhiro

  Department Of Industrial Chemistry Faculty Of Engineering Seikei University

• Nishiyama Yasuhiro

  Department Of Applied Chemistry Osaka University

• Yamamoto Naoki

  Department Of Bioinformatics Faculty Of Engineering Soka University

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