Regioselective Conjugation of Chitosan with a Laminin-related Peptide, Tyr-Ile-Gly-Ser-Arg, and Evaluation of Its Inhibitory Effect on Experimental Cancer Metastasis
スポンサーリンク
概要
- 論文の詳細を見る
A conjugate from the YIGSR peptide and chitosan has been prepared on the basis of a regioselective modification strategy of chitosan, and its antimetastatic activity has been assayed. Chitosan was converted to its organosoluble derivative, 6-O-trityl-chitosan, in 3 steps, and then coupled with the peptide portion containing a spacer amino acid, Ac-Tyr-Ile-Gly-Ser-Arg-βAla-OH [βAla; β-alanine]. The product was treated with CHCl_2CO_2H to afford the desired conjugate, Ac-Tyr-Ile-Gly-Ser-Arg-βAla-chitosan, which proved to inhibit the experimental lung metastasis of B16BL6 melanoma cells in mice at lower doses than the parent peptide.
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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Mayumi Tadanori
Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University
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Kiwada Hiroshi
徳島大学 ヘルスバイオサイエンス研究部薬物動態制御学
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Kiwada Hiroshi
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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Nishiyama Yasuhiro
Department of Cardiology, Kurume University Medical Center
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村上 智彦
神戸学院大学 薬
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TSUTSUMI Yasuo
Graduate School of Pharmaceutical Sciences, Osaka University
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Higashisaka Kazuma
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Kamada Haruhiko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Kamada Haruhiko
Laboratory Of Pharmaceutical Proteomics (lpp) National Institute Of Biomedical Innovation (nibio)
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Tsutsumi Y
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Faculty Of Pharmaceutical Sciences The Universit
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kamiya Hiroyuki
Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Keiko Hojo
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Hojo Keiko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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Kamada H
Yamagata Technopolis Foundation Yamagata Jpn
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Kamada Hitoshi
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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KAMADA Haruhiko
Graduate School of Pharmaceutical Sciences, Osaka University
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YOSHIKAWA Tomoko
Department of Industrial Chemistry, Faculty of Engineering, Seikei University
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KURITA Keisuke
Department of Industrial Chemistry, Faculty of Engineering, Seikei University
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Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Mayumi Tadanori
Faculty Of Pharmacy Osaka University
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Kamada H
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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Kiwada H
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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Tsutsumi Yasuo
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Kurita K
Department Of Applied Chemistry Faculty Of Engineering Seikei University
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Kurita Keisuke
Department Of Applied Chemistry Faculty Of Engineering Seikei University
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Kurita Keisuke
Department Of Materials And Life Science Faculty Of Science And Technology Seikei University
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Hojo Keiko
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Nishiyama Y
Department Of Pathology And Laboratory Medicine The University Of Texas-houston Medical School
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Nishiyama Yasuhiro
Department Of Applied Chemistry Osaka University
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Subdivision Of Biopharmaceutical Science Institu
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Yoshikawa Tomoaki
Department Of Toxicology And Safety Science Graduate School Of Pharmaceutical Sciences Osaka Univers
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Nishiyama Y
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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Yoshikawa Tomoko
Department Of Biology University Of Virginia
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