DNA Microarray Analysis of Type 2 Diabetes-Related Genes Co-regulated between White Blood Cells and Livers of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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概要
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In a previous study, we hypothesized that some type 2 diabetes mellitus susceptible genes may be up/downregulated in white blood cells (WBC) of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, reflecting their up/down-regulation in major insulin-target tissues such as the liver before the onset of diabetes. We identified 57 potential candidate genes for predicting diabetes. In this study, we examined this hypothesis further by extending the experimental conditions from before the onset (6 weeks) to after the onset (24 weeks) of diabetes that type 2 diabetes mellitus susceptible genes are co-regulated in WBC, reflecting their expression in the liver. Using rat oligo DNA microarrays, we found that 48 genes are up/down-regulated in OLETF rats compared to control Long-Evans Tokushima Otsuka (LETO) rats in WBC and liver under fasting or insulin administration conditions. Twenty nine and 33 genes were up/down-regulated in both WBC and livers, respectively, under fasting and insulin administration conditions, respectively. Eight out of 29 genes in fasting condition and 12 out of 33 genes in insulin administration conditions have been reported to be type 2 diabetes mellitus susceptible genes and the remainder have not been reported to be related to type 2 diabetes mellitus. These results support our hypothesis that the expression levels of type 2 diabetes mellitus related genes in WBC are reflective of those in the liver after the onset of diabetes.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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Kamiya Hiroyuki
Faculty of Pharmaceutical Sciences, Hokkaido University
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Kiwada Hiroshi
徳島大学 ヘルスバイオサイエンス研究部薬物動態制御学
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Subdivision Of Biopharmaceutical Sciences Instit
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Kiwada Hiroshi
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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原島 秀吉
北大院・薬学研究科
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Kamada Haruhiko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Faculty Of Pharmaceutical Sciences The Universit
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Kamiya Hiroyuki
Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Sato Y
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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Baba Yoshinobu
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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馬場 嘉信
徳島大学薬学部薬品物理化学教室
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Shim Chang
Faculty Of Pharmaceutical Sciences University Of Tokyo : (present Address) College Of Pharmacy Seoul
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SAWADA Akihiro
Department of Radiology, Saga Medical School
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Sawada Akihiro
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Kasai Hiroshi
Inst. Of Industrial Ecological Sciences Univ. Of Occupational And Environmental Health 1-1 Iseigaoka
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HARASHIMA Hideyoshi
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido Unive
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Baba Yoshinobu
Dep. Of Applied Chemistry Graduate School Of Engineering Nagoya Univ.
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Baba Yoshinobu
Department Of Applied Chemistry Graduate School Of Engineering Mext Innovative Research Center For P
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Hayashi Yasuhiro
Laboratory of Innovative Nanomedicine, Graduate School of Pharmaceutical Sciences, Hokkaido Universi
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Iida Shinya
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido Unive
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Sato Yuichiro
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido Unive
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Kaji Noritada
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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Kamiya Hiroyuki
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido Unive
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NAKAYA Akihiro
Department of Computational Biology, University of Tokyo
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Kaji Noritada
Mext Innovative Res. Center For Preventive Medical Engineering Nagoya Univ.
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Nakaya Akihiro
Department Of Computational Biology University Of Tokyo
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Harashima Hideyoshi
Laboratory For Molecular Design Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokkaido Univers
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Harashima Hideyoshi
Department Of Pharmacokinetics And Pharmaceutics Graduate School Of Pharmaceutical Sciences The Univ
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Kamiya Hiroyuki
産業医科大学産業生態科学研究所
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Murata-kamiya Naoko
Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.
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馬場 嘉信
Crest
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馬場 嘉信
徳島大学薬学部
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Hayashi Yasuhiro
Department Of Surgical Oncology Graduate School Of Medicine Hokkaido University
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Kamiya Hiroyuki
Faculty Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology
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馬場 嘉信
名古屋大学大学院工学研究科
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Kaji Noritada
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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KAMIYA Hiroyuki
Laboratory for Molecular Design of Pharmaceutics and COE Program in the 21st Century, Graduate School of Pharmaceutical Sciences, Hokkaido University
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HARASHIMA Hideyoshi
Laboratory for Molecular Design of Pharmaceutics and COE Program in the 21st Century, Graduate School of Pharmaceutical Sciences, Hokkaido University
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