Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract
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概要
- 論文の詳細を見る
The mutagenicity of oxidized adenine, 2-hydroxyadenine (2-OH-Ade), was examined using an SV40 origindependent in vitro replication system with a HeLa extract. 2-OH-Ade was mutagenic with an induced mutation frequency of 0.03-0.8%. 2-OH-Ade mainly caused deletion and A→G mutations. These results indicate that 2-OH-Ade is mutagenic under in vitro replication conditions. The mutation spectrum of 2-hydroxy-dATP in in vitro replication, obtained in a previous study, is discussed.
- 日本環境変異原学会の論文
- 2006-08-31
著者
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Kamiya Hiroyuki
Faculty of Pharmaceutical Sciences, Hokkaido University
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Harashima Hideyoshi
Faculty of Pharmaceutical Sciences, Hokkaido University
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原島 秀吉
北大院・薬学研究科
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KASAI HIROSHI
Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
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Kasai Hiroshi
Inst. Of Industrial Ecological Sciences Univ. Of Occupational And Environmental Health 1-1 Iseigaoka
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Satou Kazuya
Faculty of Pharmaceutical Sciences, Hokkaido University
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Harashima Hideyoshi
Department Of Pharmacokinetics And Pharmaceutics Graduate School Of Pharmaceutical Sciences The Univ
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Kamiya Hiroyuki
産業医科大学産業生態科学研究所
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Murata-kamiya Naoko
Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.
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Kasai Hiroshi
Institute Of Industrial Ecological Sciences Department Of Environmental Oncology University Of Occup
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Kamiya Hiroyuki
Faculty Of Pharmaceutical Sciences Hokkaido University
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Harashima Hideyoshi
Faculty Of Pharmaceutical Science The University Of Tokushima
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Kaji Hiroshi
Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.
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Kamiya Hiroyuki
Faculty Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology
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