Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract

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概要

• 論文の詳細を見る

• The mutagenicity of oxidized adenine, 2-hydroxyadenine (2-OH-Ade), was examined using an SV40 origindependent in vitro replication system with a HeLa extract. 2-OH-Ade was mutagenic with an induced mutation frequency of 0.03-0.8%. 2-OH-Ade mainly caused deletion and A→G mutations. These results indicate that 2-OH-Ade is mutagenic under in vitro replication conditions. The mutation spectrum of 2-hydroxy-dATP in in vitro replication, obtained in a previous study, is discussed.

• 日本環境変異原学会の論文
• 2006-08-31

著者

• Kamiya Hiroyuki

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Harashima Hideyoshi

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 原島 秀吉

  北大院・薬学研究科

• KASAI HIROSHI

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Kasai Hiroshi

  Inst. Of Industrial Ecological Sciences Univ. Of Occupational And Environmental Health 1-1 Iseigaoka

• Satou Kazuya

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Harashima Hideyoshi

  Department Of Pharmacokinetics And Pharmaceutics Graduate School Of Pharmaceutical Sciences The Univ

• Kamiya Hiroyuki

  産業医科大学産業生態科学研究所

• Murata-kamiya Naoko

  Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.

• Kasai Hiroshi

  Institute Of Industrial Ecological Sciences Department Of Environmental Oncology University Of Occup

• Kamiya Hiroyuki

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Harashima Hideyoshi

  Faculty Of Pharmaceutical Science The University Of Tokushima

• Kaji Hiroshi

  Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.

• Kamiya Hiroyuki

  Faculty Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology

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