Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes
スポンサーリンク
概要
- 論文の詳細を見る
Base oxidation occurs in the cellular nucleotide pool as well as in DNA, and the oxidized DNA precursors induce mutagenic events. 8-Hydroxy-dGTP (8-OH-dGTP) and 2-hydroxy-dATP (2-OH-dATP) have been identified as the major products of in vitro oxidation reactions with Fe2+. The mutagenic potentials of many oxidized DNA precursors have been examined in various experimental systems. Accumulating evidence indicates the importance of 8-OH-dGTP and 2-OH-dATP in the mutation process. In addition, nucleotide pool sanitization enzymes, such as MutT and MTH1, have been identified as a defense against the mutagenesis induced by these oxidized DNA precursors. In this review, the mutagenicities of 8-OH-dGTP and 2-OH-dATP and the functions of MutT-type nucleotide pool sanitization enzymes will be summarized.
- 2007-11-30
著者
-
Kamiya Hiroyuki
Faculty of Pharmaceutical Sciences, Hokkaido University
-
Kamiya Hiroyuki
Faculty Of Pharmaceutical Sciences Hokkaido University
関連論文
- Transgene expression efficiency from plasmid DNA delivered as a complex with histone H3
- Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5
- UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides
- Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes
- Correlation between the Phosphohydrolase Activity of the Escherichia coli Orf135 (NudG) Protein and Mutation Suppression
- Effects of Overexpression and Antisense RNA Expression of Orf17, a MutT-Type Enzyme
- MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion
- Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein
- New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX
- DNA Microarray Analysis of Type 2 Diabetes-Related Genes Co-regulated between White Blood Cells and Livers of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
- Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells
- Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract
- Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases
- Cytotoxic Effect of Drosophila Deoxynucleoside Kinase Gene on Replicating Plasmid in HeLa Cells
- Induction of Various Mutations during PCRs with Manganese and 8-Hydroxy-dGTP
- PK-PD modeling of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes
- Correction of Frameshift Mutations with Single-Stranded and Double-Stranded DNA Fragments Prepared from Phagemid/Plasmid DNAs(Miscellaneous)
- RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells
- Effects of Target Sequence and Sense versus Anti-sense Strands on Gene Correction with Single-stranded DNA Fragments
- Effects of non-B DNA sequences on transgene expression
- Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression.
- Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription.
- Comparison of Incorporation and Extension of Nucleotides in vitro opposite 8-Hydroxyguanine (7,8-Dihydro-8-oxoguanine) in Hot Spots of the c-Ha-ras Gene
- Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria.
- Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7, 8-dihydroguanine (8-Hydroxyguanine)
- Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.
- Correction of Frameshift Mutations with Tailed Duplex DNAs
- Effects of Endogenous Proteins and microRNA Target Sequence in a Positive Feedback System
- Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver