Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver
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概要
- 論文の詳細を見る
Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.
- 公益社団法人 日本薬学会の論文
著者
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Kamiya Hiroyuki
Faculty of Pharmaceutical Sciences, Hokkaido University
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Harashima Hideyoshi
Faculty of Pharmaceutical Sciences, Hokkaido University
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Sawada Akihiro
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Baba Yoshinobu
Department Of Applied Chemistry Graduate School Of Engineering Mext Innovative Research Center For P
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Kamiya Hiroyuki
Faculty Of Pharmaceutical Sciences Hokkaido University
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Harashima Hideyoshi
Faculty Of Pharmaceutical Science The University Of Tokushima
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Iida Shinya
Faculty Of Bioresources Mie University
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Kaji Noritada
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Nakaya Akihiro
Center for Transdisciplinary Research, Niigata University
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Hayashi Yasuhiro
Faculty of Pharmaceutical Sciences, Hokkaido University
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Baba Yoshinobu
Department of Applied Chemistry, Graduate School of Engineering, FIRST Research Center for Nanobiodevices, Nagoya University
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Kaji Noritada
Department of Applied Chemistry, Graduate School of Engineering, FIRST Research Center for Nanobiodevices, Nagoya University
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Iida Shinya
Faculty of Pharmaceutical Sciences, Hokkaido University
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