PREDICTION OF SERUM CONCENTRATION TIME COURSE OF QUINIDINE IN HUMAN USING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL DEVELOPED FROM THE RAT

概要

論文の詳細を見る
Serum concentration-time courses of quinidine in humans were predicted by a physiologically based pharmacokinetic model developed from the rat using reported values for the serum protein binding, blood-to-serum concentration ratio, renal clearance and physiological constants, i.e. tissue volume and blood flow rate of each tissue. The tissue binding parameters of the rat were used for humans. The hepatic intrinsic clearance (CL_<H, int>) of quinidine for human was extrapolated by using the relation between CL_<H, int> of humans and those of the rat reported for antipyrine, phenytoin and hexobarbital. The predicted time course were comparable with the observed data in humans obtained from the literature, though slight differences were shown in the half-lives between the observed data and the predicted curves. It was suggested that the overestimation of the tissue binding parameters might be the cause of this difference.
社団法人日本薬学会の論文