In Vitro-in Vivo Correlation of Pharmacodynamics of Felodipine in Essential Hypertensive Patients Based on an Ion-Channel Binding Model
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between the plasma drug concentration and the antihypertensive effect of felodipine was analyzed by an ion-channel binding model which takes into consideration the slow association/dissociation process of a drug at the calcium channel. The in vitro dissociation constant (K_d) of felodipine to the calcium channel in the heart of rats was determined, and was compared to the in vivo dissociation constant (D_<d, calc>) estimated by the pharmacodynamic analysis of the concentration-effect data in Japanese essential hypertensive patients obtained from literature. The relative relationship between K_d and K<d, calc> of felodipine was substantially identical with eight other calcium channel blocking agents reported previously. This result suggested the possibility that we can predict the pharmacodynamic behavior of newly developed calcium channel blocking agents from the in vitro K_d value and plasma concentration-time profile in human using the ion-channel binding model.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
-
Nakajima Yukiko
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
-
YAMAMOTO Koujirou
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
-
IGA Tatsuji
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
-
Shimada S
Univ. Tokyo Tokyo
-
Shimada Shuji
東京大学医学部附属病院 薬剤
-
SAWADA Yasufumi
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
Shimada Shuji
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and
-
Sawada Y
Department Of Pharmaceutics Graduate School Of Pharmacertical Sciences Kyushu University
-
Sawada Yasufumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Uni
-
KOTAKI Hajime
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
-
IGA Tatsuji
International University of Health and Welfare
-
Kotaki Hajime
Department Of Pharmacy Faculty Of Medicine University Of Tokyo
-
Nakajima Yukiko
Department Of Pharmaceutics Kyoritsu College Of Pharmacy
-
Yamamoto Koujirou
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
-
Yamamoto Koujirou
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine:department
-
Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University School Of Medicine
-
Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University Graduate School Of Medicine
-
Iga T
Department Of Pharmacy University Of Tokyo Hospital
-
Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
-
Kotaki H
Univ. Tokyo Tokyo Jpn
-
Shimada Shuji
Department Of Clinical Pharmacology Graduate School Of Pharmaceutical Sciences Toyama Medical And Ph
-
Nakada Y
Nippon Organon K. K. Osaka Jpn
-
Iga T
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
-
Yamano Katsuhiro
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
KOTAKI Hajime
Department of Pharmacy, The Research Hospital, The Institute of Medical Science, The University of Tokyo
関連論文
- Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains
- ニューキノロン系抗菌薬12種と非ステロイド性消炎鎮痛薬5種の組み合わせに関する痙攣誘発活性の網羅的比較
- INHIBITION OF GABA_A RECEPTOR-MEDIATED CURRENT RESPONSES BY ENOXACIN (NEW QUINOLONE) AND FELBINAC (NON-STEROIDAL ANTI-INFLAMMATORY DRUG) IN XENOPUS OOCYTES INJECTED WITH MOUSE-BRAIN MESSENGER RNA
- Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside
- Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats
- HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Puerariae Flos
- Inhibitory Effect of Azole Antifungal Agents on the Glucuronidation of Lorazepam Using Rabbit Liver Microsomes in Vitro
- Total body propofol clearance (TBPC) after living-donor liver transplantation (LDLT) surgery is decreased in patients with a long warm ischemic time
- Pharmacobezoar complicating treatment with sodium alginate
- 透析患者におけるジゴキシン消失に及ぼすOATP1B3遺伝子多型の影響
- Polymorphisms and Linkage Disequilibrium of the OATP8 (OATP1B3) Gene in Japanese Subjects
- Polymorphism of MDR1 Gene in healthy Japanese Subjects : A Novel SNP with an Amino Acid Substitution (Glu108Lys)
- Progressive Bone Loss due to Androgen Deprivation Therapy for Prostate Cancer : A Meta-analysis
- Inhibitory Effects of Nicardipine to Cytochrome P450 (CYP) in Human Liver Microsomes(Biopharmacy)
- Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)(Biopharmacy)
- Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene
- BILIARY EXCRETION AND ENTEROHEPATIC CYCLING OF GLYCYRRHIZIN IN RATS
- Prediction of the Pharmacokinetics of Cefodizime and Cefotetan in Humans from Pharmacokinetic Parameters in Animals
- QUANTITATIVE RELATIONSHIP BETWEEN IN VIVO BENZODIAZEPINE RECEPTOR OCCUPANCY AND CEREBRAL METABOLIC CHANGE IN THE MOUSE
- RENAL HANDLING OF EPIDERMAL GROWTH FACTOR IN ISOLATED PERFUSED RAT KIDNEY
- BINDING, INTERNALIZATION AND DEGRADATION OF ATRIAL NATRIURETIC PEPTIDE IN ISOLATED CHOROID PLEXUS
- COMPARATIVE ANALYSIS OF HEPATIC UPTAKE AND BILIARY EXCRETION OF VINCRISTINE AND VINBLASTINE IN PERFUSED RAT LIVER
- DOWN REGULATION OF EPIDERMAL GROWTH FACTOR (EGF) RECEPTOR IN THE PERFUSED RAT LIVER : RECOVERY OF THE CELL SURFACE FREE RECEPTOR
- Effect of Quinidine on the Hepatic Uptake of Digoxin in Guinea Pigs
- FACILITATED TRANSPORT OF BENZYLPENICILLIN THROUGH THE BLOOD-BRAIN BARRIER IN RATS
- Kinetic Analysis of the Positive Inotropic Action (PIA) of Ouabain in Isolated Perfused Rabbit Heart. Slow Onset of PIA and Slow Binding to Na^+, K^+-Adenosine Triphosphatase
- THE TRANSPORT SYSTEM OF BENZYLPENICILLIN IN THE BLOOD-CEREBROSPINAL FLUID BARRIER
- THE EFFECT OF BASIC DRUGS ON THE HEPATIC TRANSPORT OF CARDIAC GLYCOSIDES IN RATS
- PHARMACOKINETIC STUDY OF 4-METHYLUMBELLIFERONE IN MICE
- KINETICAL ANALYSIS OF HEPATIC TRANSPORT OF EPIDERMAL GROWTH FACTOR (EGF) IN THE PERFUSED RAT LIVER
- THE TRANSPORT SYSTEM OF CIMETIDINE FROM THE RAT CEREBROSPINAL FLUID : IN VIVO AND IN VITRO STUDIES
- COMPARATIVE UPTAKE OF CIMETIDINE BY RAT CHOROID PLEXUS BETWEEN THE LATERAL AND THE 4TH VENTRICLES
- PREDICTION OF SERUM CONCENTRATION TIME COURSE OF QUINIDINE IN HUMAN USING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL DEVELOPED FROM THE RAT
- PREDICTION OF THE PLASMA CONCENTRATION TIME COURSES OF VARIOUS DRUGS IN HUMANS BASED ON DATA FROM RATS
- KINETICS OF HEPATIC TRANSPORT OF 4-METHYLUMBELLIFERONE IN RATS : ANALYSIS BY MULTIPLE INDICATOR DILUTION METHOD
- KINETIC ANALYSIS OF RENAL TUBULAR TRANSPORT OF CIMETIDINE IN RATS BASED ON MULTIPLE INDICATOR DILUTION STUDIES
- INTERACTION OF OUABAIN AND ROSE BENGAL WITH RAT LIVER PLASMA MEMBRANES
- Dynamic Structures of Granulocyte Colony-Stimulating Factor Proteins Studied by Normal Mode Analysis : Two Domain-Type Motions in Low Frequency Modes
- KINETIC ANALYSIS OF DISPOSITION OF HUMAN EPIDERMAL GROWTH FACTOR (EGF) : ANALYSIS USING FRESHLY ISOLATED RAT HEPATOCYTE AND ANALYSIS OF RECEPTOR DYNAMICS IN ORGANS IN VIVO
- Kinetic Study on the Mechanism of Tissue Distribution of Vinblastine
- POSSIBLE MECHANISMS FOR THE CHANGES IN MICROCLIMATE-pH IN THE RAT SMALL INTESTINE AND EFFECTS OF PHENOTHIAZINE DERIVATIVES IN VIVO
- In Vitro-in Vivo Correlation of Pharmacodynamics of Felodipine in Essential Hypertensive Patients Based on an Ion-Channel Binding Model
- Comparative Pharmacodynamics of Eight Calcium Channel Blocking Agents in Japanese Essential Hypertensive Patients
- プロポフォール薬物動態と心拍出量
- Thiopurine Methyltransferase Genotype and Phenotype Status in Japanese Patients with Systemic Lupus Erythematosus(Biopharmacy)
- Treatment of Natto, a Fermented Soybean Preparation, to Prevent Excessive Plasma Vitamin K Concentrations in Patients Taking Warfarin
- Effect of Renal Failure on Neurotoxicity of Ranitidine in Rats
- Effect of Cisplatin on the Disposition of Endogenous Serotonin and Its Main Metabolite, 5-Hydroxyindole-3-acetic Acid, in Rats and Dogs
- Genotyping of Thiopurine Methyltransferase Using Pyrosequencing^(Biopharmacy)
- Kinetic Analysis of Effects of Mouth Washing on Removal of Drug Residues Following Inhalation of Fluticasone Propionate Dry Powder(Biopharmacy)
- Neurotoxic Convulsions Induced by Theophylline and Its Metabolites in Mice
- INDUCIBLE RESISTANCE TO A 16-MEMBERED MACROLIDE, MYCINAMICIN, IN STAPHYLOCOCCUS AUREUS RESISTANT TO 14-MEMBERED MACROLIDES AND STREPTOGRAMIN B ANTIBIOTICS
- MACROLIDE ANTIBIOTICS WHICH INHIBIT THE GROWTH OF STAPHYLOCOCCUS AUREUS RE-SISTANT TO PARTIAL MACROLIDE ANTIBIOTICS
- GREATLY IMPROVED ACTIVITY OF STAPHYLOCOCCAL RIBOSOMES IN POLYADENYLATE DIRECTED POLYLYSINE SYNTHESIS : AS AN ASSAY SYSTEM FOR INVESTIGATING THEIR SENSITIVITY TO MACROLIDE ANTIBIOTICS
- RESISTANCE TO MACROLIDES : STAPHYLOCOCCAL RIBOSOMES THAT DO NOT SHOW CORESISTANCE TO MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN B ANTIBIOTICS
- A MODE OF RESISTANCE TO MACROLIDE ANTIBIOTICS : REGARDING STAPHYLOCOCCUS AUREUS THAT DOES NOT SHOW MLS-CORESISTANCE
- RESISTANCE TO MACROLIDE ANTIBIOTICS IN STAPHYLOCOCCUS AUREUS SUSCEPTIBLE TO LINCOMYCIN AND MIKAMYCIN B : A NEW GROUP OF CONSTITUTIVE RESISTANT STRAINS
- Physiologically-based Pharmacokinetic Analysis of Grepafloxacin
- Pharmacokinetic and Pharmacodynamic Analysis of the Antihypercalcemic Effect of Incadronate Disodium in Rats
- Preparation and Characterization of Polylactic Acid Microspheres Containing Water-Soluble Anesthetics with Small Molecular Weight
- NUCLEAR BINDING AS A DETERMINANT OF TISSUE DISTRIBUTION OF ADRIAMYCIN, DAUNOMYCIN, ADRIAMYCINOL, DAUNORUBICINOL AND ACTINOMYCIN D
- A Comparative Pharmacodynamic Study of the Arrhymogenicity of Antidepressants, Fluvoxamine and Imipramine, in Guinea Pigs
- Pharmacokinetic/Pharmacodynamic Analysis of Tacrolimus-Induced QT Prolongation in Guinea Pigs
- VARIATION IN D-GLUCOSE UPTAKE ALONG THE INTESTINAL TRACT
- A LAMINAR FLOW ABSORPTION MODEL FOR A CARRIER-MEDIATED TRANSPORT IN THE INTESTINAL TRACT
- A DRUG ABSORPTION MODEL OF THE INTESTINAL TRACT BASED ON THE TWO-DIMENSIONAL LAMINAR FLOW IN A CIRCULAR TUBE
- Determination of Isepamicin in Human Plasma by HPLC with Fluorescence Detection after Derivatization Using 6-Aminoquinolyl-N-hydroxysuccinimidyl-carbamate(Analytical Biochemistry)
- A novel intronic mutation that may affect genotyping result of CYP2C8 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is strongly associated with CYP2C8^*3 in a South American population
- Time-Dependent Induction of Midazolam-1-hydroxylation Enzymes in Rats Treated with St. John's Wort(Biopharmacy)
- CYP3A4^*18 : It is not Rare Allele in Japanese Population
- Successful Treatment of Severe Hyperammonemia Using Sodium Phenylacetate Powder Prepared in Hospital Pharmacy
- Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir and nelfinavir in human plasma by high-performance liquid chromatography
- Quantitative determination of domperidone in rat plasma by high-performance liquid chromatography with fluorescence detection
- Relationship between the First-Order Intestinal Absorption Rate Constant in Vivo and the Membrane Permeability Clearance in a Perfusion System : An Intragastric Administration Method in Vivo
- SIGNIFICANCE OF 17-HYDROXYCORTICOSTEROIDS GLUCURONIDE IN URINE AS AN INDEX OF SALICYLAMIDE GLUCURONIDATION IN GUINEA PIGS
- Kinetic Analysis of Phenytoin Disposition in Rats with Experimental Renal and Hepatic Diseases
- 内因性ドパミンの受容体結合占有に着目した定型および非定型抗精神病薬の錐体外路系副作用の定量的予測
- Effect of Mixing Method on the Mixing Degree during the Preparation of Triturations
- Saturable Binding of Finasteride to Steroid 5α-reductase as Determinant of Nonlinear Pharmacokinetics
- Inhibitory Effects of Herbal Extracts on Breast Cancer Resistance Protein (BCRP) and Structure-Inhibitory Potency Relationship of Isoflavonoids
- Neurotoxic Study of H_2 Antagonists Using Xenopus Oocytes Injected with Mouse-Brain mRNA
- Effect of Acute Renal Failure on Neurotoxicity of Enoxacin in Rats
- Lack of Potentiation with Felbinac Patch on the Convulsive Toxicity of Enoxacin in Rats
- Effect of Acute Renal Failure on the Distribution of Iomeprol, a Nonionic Contrast Agent, to Cerebrospinal Fluid in Rats
- Efeects of Single and Repeated Treatment with Itraconazole on the Pharmacokinetics of Midazolam in Rats
- Pharmacokinetic/Pharmacodynamic Analysis of Neutrophil Proliferation Induced by Recombinant Granulocyte Colony-Stimulating Factor (rhG-CSF) : Comparison between Intravenous and Subcutaneous Administration
- Determination of erythromycin concentrations in rat plasma and liver by high-performance liquid chromatography with amperometric detection
- Pharmacokinetic-Pharmacodynamic Analysis of the Electrocardiographic Effects of Terfenadine and Quinidine in Rats
- Quantitative determination of epinastine in plasma by high-performance liquid chromatography
- Inhibition of Vinblastine Efflux Mediated by P-Glycoprotein by Grapefruit Juice Components in Caco-2 Cells
- PHYSIOLOGICAL PHARMACOKINETICS OF TOLBUTAMIDE-SULFONAMIDES INTERACTION IN RATS
- Tolbutamide Uptake Via pH- and Membrane-potential-dependent Transport Mechanism in Mouse Brain Capillary Endothelial Cell Line
- SATURABLE TRANSPORT OF CIMETIDINE FROM CEREBROSPINAL FLUID TO BLOOD IN RATS
- ESTIMATION OF RENAL BLOOD FLOW BY USE OF ENDOGENOUS N^1-METHYLNICOTINAMIDE IN RATS
- EFFECT OF PREGNANCY ON TISSUE DISTRIBUTION OF SALICYLATE IN THE RAT
- EFFECT OF EXPERIMENTAL ACUTE RENAL FAILURE ON INTRINSIC RENAL TUBULAR SECRETORY CLEARANCE OF ORGANIC CATIONS IN RATS
- PREDICTION OF RENAL SECRETORY CLEARANCE OF ORGANIC CATIONIC DRUGS BY ENDOGENOUS N^1-METHYLNICOTINAMIDE IN RATS WITH EXPERIMENTAL RENAL FAILURE
- PREDICTION OF RENAL TUBULAR SECRETION OF TETRAETHYLAMMONIUM BROMIDE BY USE OF ENDOGENOUS N^1-METHYLNICOTINAMIDE IN THE RAT
- EFFECT OF HEPARIN INJECTION ON PLASMA PROTEIN BINDING OF 1-ANILINO-8-NAPHTHALENESULFONATE AND SALICYLATE IN RATS
- Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)