Effect of Cisplatin on the Disposition of Endogenous Serotonin and Its Main Metabolite, 5-Hydroxyindole-3-acetic Acid, in Rats and Dogs
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概要
- 論文の詳細を見る
Emesis after the administration of cisplatin is a severe complication, and its treatment is an important problem clinically. Cisplatin forces the release of serotonin (5-HT) from enterochromaffin cells in the mucosa, and emesis occurs by the stimulation of 5-HT_3 receptors. In this study, we established a simple and simultaneous method of determining 5-HT and its main metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA), in plasma and urine by high performance liquid chromatography with electrochemical detection (HPLC-ECD), and determined the disposition of endogenous 5-HT and 5-HIAA after the administration of cisplatin in rats and dogs. In rats, we found no change in the plasma concentration of 5-HIAA after cisplatin administration, while a distinct increase was shown in the plasma concentration of 5-HT, but it was not significantly different from that of the control rats. The urinary excretion of 5-HIAA was also not different between the two groups. In dogs, we observed intense vomiting in all cisplatin treated dogs. However, we could not detect any change in the 5-HIAA or 5-HT level in the dog plasma. Furthermore, no significant difference in the urinary excretion of 5-HIAA was observed between the cisplatin group and the controls. From these results, the plasma concentration of 5-HT and the urinary excretion of 5-HIAA may not be suitable markers for the evaluation of emesis induced by anticancer drugs in dogs.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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YAMADA Yasuhiko
Department of Mathematics, Faculty of Science, Kobe University
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Nakajima Yukiko
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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YAMAMOTO Koujirou
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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SAWADA Yasufumi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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IGA Tatsuji
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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Sawada Yasufumi
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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Nakajima Y
Ohta's Isan Co. Ltd. Ibaraki Jpn
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Nakajima Yukiko
Department Of Pharmaceutics Kyoritsu College Of Pharmacy
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Yamada Yasuhiko
Department Of Clinical Evaluation Of Drug Efficacy School Of Pharmacy Tokyo University Of Pharmacy A
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Yamada Yasuhiko
Department Of Pharmacy University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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Yamamoto Koujirou
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Yamamoto Koujirou
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine:department
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University Graduate School Of Medicine
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Iga T
Department Of Pharmacy University Of Tokyo Hospital
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Nakada Y
Nippon Organon K. K. Osaka Jpn
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Yamada Yasuhiko
Department Of Clinical Evaluation Of Drug Efficacy School Of Pharmacy Tokyo University Of Pharmacy A
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Yamada Yasuhiko
Department Of Clinical Evaluation Of Drug Efficacy School Of Pharmacy Tokyo University Of Pharmacy A
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