Successful Treatment of Severe Hyperammonemia Using Sodium Phenylacetate Powder Prepared in Hospital Pharmacy
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概要
- 論文の詳細を見る
In order to treat a hyperammonemic patient with adult-onset type-II citrullinemia (CTLN2), sodium phenylacetate powder was prepared from chemical reagent grade phenylacetic acid in Gunma University Hospital. After purification by recrystalization, phenylacetic acid was neutralized with sodium carbonate and dried at 70℃ under reduced pressure. A solution of the prepared powder produced a single peak of m/z 181.0 (M + Na^+) in electrospray-ionization-MS spectrogram. The content of phenylacetate was 74% of theoretical value, suggesting the existence of water of crystallization. The content of phenylacetate remained constant for 5 months under dark conditions at room temperature. The prepared sodium phenylacetate powder was orally administered to a 16-year-old patient with CTLN2 at a dosage of 12 g/d. The serum ammonia concentration of the patient, who did not show adequate response to intravenous arginine or oral sodium benzoic acid decreased remarkably to less than 100 μg/dl. Sodium phenylacetate powder should be an essential drug for the treatment of hyperammonemia caused by an inborn error of the urea cycle.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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Tomomasa Takeshi
Department of Pediatrics, Gunma University School of Medicine
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YAMAMOTO Koujirou
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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KANEKO HIROAKI
Department of Pediatrics, Gunma University School of Medicine
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HORIUCHI RYUYA
Department of Clinical Pharmacology, Gunma University Graduate School of Medicine
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Honda Shigeru
Department Of Pharmacy Gunma University School Of Medicine
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Horiuchi Ryuya
Department Of Pharmacy Gunma University School Of Medicine:department Of Clinical Pharmacology Gunma
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Kaneko H
Department Of General Surgical Science (surgery I) Graduate School Of Medicine Gunma University
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Kaneko Hiroaki
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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OSHIMA Yasuo
Department of Hematology, Takagi Hospital
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Yamamoto Keiko
Department Of Pharmaceutics
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Tomomasa Takeshi
Department Of Pediatrics And Developmental Medicine Gunma University Graduate School Of Medicine
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Tomomasa Takeshi
Department Of Paediatrics Gunma University School Of Medicine
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Yamamoto Koujirou
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Yamamoto Koujirou
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine:department
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University School Of Medicine
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University Graduate School Of Medicine
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Oshima Yasuo
Department Of Pharmacy Gunma University School Of Medicine
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Oshima Yasuo
Department Of Hematology Takagi Hospital
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SEIZUKA Masayuki
Department of Pharmacy, Gunma University School of Medicine
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NAGAI Kazumi
Department of Pharmacy, Gunma University School of Medicine
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HASHIMOTO Gen-ichi
Department of Pharmacy, Gunma University School of Medicine
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KONNO Yuko
Department of Clinical Pharmacology Gunma University School of Medicine
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Horiuchi Ryuya
Department Of Clinical Pharmacology And Department Of Pharmacy Gunma University School Of Medicine
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Kuwano Hiroyuki
Department Of General Surgical Science And 21st Century Coe Program Graduate School Of Medicine Gunm
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Nagai Kazumi
Department Of Pharmacy Gunma University School Of Medicine
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Seizuka Masayuki
Department Of Pharmacy Gunma University School Of Medicine
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Hashimoto Gen-ichi
Department Of Pharmacy Gunma University School Of Medicine
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Yamano Katsuhiro
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Honda Shigeru
Department Of Medicine Ii Niigata University School Of Medicine
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Sekizuka Masayuki
Department of Pharmacy, Gunma University School of Medicine
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Honda Shigeru
Department of Pharmacy, Gunma University School of Medicine
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