Effect of Endotoxin on Colonic Motility in Conscious Rats
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概要
- 論文の詳細を見る
Background & Aims : Lipopolysaccharide-induced colonic dysmotility using an in vivo rat model was examined in this study. Methods: Six days prior to the experiment, force transducers were sutured to the proximal colons of the rats. On the day of the experiment, while monitoring colonic contractions, lipopolysaccharide (LPS) (Img/kg) was given intravenously. Results: LPS injections induced abnormal high amplitude colonic contractions within 15 to 30 min in all the rats tested. After the period of these abnormal waves, motility gradually decreased. These high amplitude contractions were partly suppressed by atropine, a nonspecific cholinergic receptor antagonist. Conclusions : These results indicate that LPS induces a transient increase in colonic motility followed by suppression in conscious rats. This increase might be mediated by cholinergic receptors.
- 北関東医学会の論文
- 2004-05-01
著者
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Takahashi Atsushi
Department of Cardiology, Yokosuka Kyosai Hospital
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高橋 篤
Department Of General Surgical Science (surgery I) Graduate School Of Medicine Gunma University
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WATANABE Toshio
Department of Gastroenterology, Osaka City University Graduate School of Medicine
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MORIKAWA Akihiro
Department of Pediatrics and Developmental Medicine, Gunma University Graduate School of Medicine
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Tomomasa Takeshi
Department of Pediatrics, Gunma University School of Medicine
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KANEKO HIROAKI
Department of Pediatrics, Gunma University School of Medicine
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Kaneko H
Department Of General Surgical Science (surgery I) Graduate School Of Medicine Gunma University
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Kaneko Hiroaki
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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Kato Hiroyuki
Department Of General Surgical Science And 21st Century Coe Program Graduate School Of Medicine Gunm
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Kuwano Hiroyuki
Department Of Pharmacy Kinki University Hospital
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Morikawa Akihiro
Department Of Pediatrics And Developmental Medicine Gunma University Graduate School Of Medicine
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Morikawa Akihiro
Arita Clinic Of Pediatrics & Pediatric Allergy
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Tomomasa Takeshi
Department Of Pediatrics And Developmental Medicine Gunma University Graduate School Of Medicine
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Tomomasa Takeshi
Department Of Paediatrics Gunma University School Of Medicine
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Watanabe Toshio
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Hussain Sarwar
Department Of Pediatrics And Developmental Medicine Gunma University Graduate School
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Arita Masahiko
Arita Clinic Of Pediatrics & Pediatric Allergy
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Takahashi Atsushi
Department Of Cardiology Akita City General Hospital
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Takahashi A
Gunma Children's Medical Center Gunma
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Kuwano Hiroyuki
Department Of General Surgical Science And 21st Century Coe Program Graduate School Of Medicine Gunm
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Morikawa Akihiro
Department Of Pediatrics And Developmental Medicine Gunma University Graduate School
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Morikawa Akihiro
Department Of Paediatrics Gunma University School Of Medicine
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Watanabe Toshio
Department Of Pediatrics And Developmental Medicine Gunma University Graduate School
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Watanabe Toshio
Department Of Electronics Faculty Of Engineering Ibaraki University
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Watanabe Toshio
Department Of Chemistry University Of Tsukuba
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Aoyagi Masahiko
Department Of Pediatrics And Developmental Medicine Gunma University Graduate School Of Medicine
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Takahashi Atsushi
Departmant Of Surgery(i) Kanazawa University School Of Medicine
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Takahashi Atsushi
Department Of General Surgical Science Gunma University School Of Medicine
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