Phenytoin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria

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概要

• 論文の詳細を見る

• The effects of phenytoin and its major metabolite, 5−(4−hydroxyphenyl)−5−phenylhydantoin(HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro.Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture.This effect may be the cause of phenytoin−induced bone loss in vivo.

• 社団法人 日本薬理学会の論文
• 2000-01-01

著者

• Takahashi Atsushi

  Department of Cardiology, Yokosuka Kyosai Hospital

• ONODERA Kenji

  Department of Pharmacology, Tohoku University School of Dentistry

• SHINODA Hisashi

  Department of Pharmacology, Tohoku University School of Dentistry

• Mayanagi Hideaki

  Department of Oral Medicine and Bioregulation, and Pediatric Dentistry, Department of Lifelong Oral

• Onodera K

  Department Of Dental Pharmacology Okayama University Graduate School Of Medicine And Dentistry

• Onodera Kenji

  Department Of Dental Pharmacology

• Takahashi A

  Clinics Of Dentistry For The Disabled Tohoku University Dental Hospital

• Takahashi Atsushi

  Department Of Cardiology Akita City General Hospital

• Mayanagi H

  Division Of Pediatric Dentistry Department Of Lifelong Oral Health Sciences Tohoku University Gradua

• Shinoda Hisashi

  Department Of Pharmacology Tohoku University School Of Dentistry

• Shinoda Hisashi

  Department Of Applied Dental Pharmacology Tohoku University Graduate School Of Dentistry

• Mayanagi Hideaki

  Division Of Pediatric Dentistry Department Of Oral Health And Development Sciences Tohoku University

• Takahashi Atsushi

  Departmant Of Surgery(i) Kanazawa University School Of Medicine

• ONODERA Kenji

  Department of Chemical Pharmacology, Tohoku College of Pharmacy

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