Pharmacological Topics of Bone Metabolism : A Novel Bisphosphonate for the Treatment of Periodontitis

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概要

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• It has been reported that the pharmacological characteristics of bisphosphonates vary depending on the side chain attached to the carbon atom of the P-C-P bond. TRK-530 is a novel synthetic bisphosphonate with an anti-oxidant methylthio-phenylthio side chain. This compound has been suggested to have both anti-inflammatory and anti–bone-resorbing effects. Such a compound could be effective for the treatment of diseases with excessive bone resorption accompanied by inflammation. We have been studying this compound as a potential therapeutic agent for periodontitis. To date, we have found that 1) TRK-530 inhibited osteoclastic bone resorption in animals and in bone organ culture, 2) both systemic and topical administration of TRK-530 prevented alveolar bone loss in animals with experimental periodontitis, 3) TRK-530 prevented prostaglandin E2 synthesis by inhibiting the expression of cyclooxygenase (COX)-2 mRNA, and 4) TRK-530 inhibited the formation of dental calculus. The above results suggest that TRK-530 might be useful for the treatment of alveolar bone loss in periodontitis.

• 社団法人 日本薬理学会の論文
• 2008-04-20

著者

• SUZUKI Keiko

  Department of Internal Medicine, Koga General Hospital

• Yamada Shoji

  Showa Univ.

• SHINODA Hisashi

  Department of Pharmacology, Tohoku University School of Dentistry

• TAKEYAMA Sadaaki

  Division of Dental Pharmacology, Department of Oral Biology ; Tohoku University Graduate School of D

• MURAKAMI Shinobu

  Department of Applied Pharmacology, Department of Oral Biology ; Tohoku University Graduate School o

• YAMADA Shoji

  Department of Dental Pharmacology, School of Dentistry, Showa University

• Suzuki Keiko

  Showa Univ.

• Shinoda Hisashi

  Department Of Applied Pharmacology Department Of Oral Biology ; Tohoku University Graduate School Of

• Shinoda Hisashi

  Department Of Applied Dental Pharmacology Tohoku University Graduate School Of Dentistry

• Takeyama Sadaaki

  Division Of Dental Pharmacology Department Of Oral Biology ; Tohoku University Graduate School Of De

• Murakami Shinobu

  Department Of Applied Pharmacology Department Of Oral Biology ; Tohoku University Graduate School Of

• Suzuki Keiko

  Department Of Internal Medicine Koga General Hospital

• Yamada Shoji

  Department Of Dental Pharmacology School Of Dentistry Showa University

• Suzuki Keiko

  Deparment Of Cardiology Cenler For Adut Diseases Osaka

• Yamada Shoji

  Department of Cellular Neurobiology, Brain Research Institute, Niigata University

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