Current Topics in Pharmacological Research on Bone Metabolism : Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts
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概要
- 論文の詳細を見る
Despite the extensive use of bisphosphonates (BPs) in the treatment of metabolic bone diseases associated with increased osteoclastic bone resorption, the precise mechanism of their action on bone metabolism is still unclear. To clarify at which stages of osteoclast differentiation and activation that BPs influence, we examined the osteoclasts generated from mononuclear precursors and osteoclasts in the calvaria by laser scanning confocal microscopy. The studies showed that BPs inhibit lipopolysaccharide- or parathyroid hormone-induced osteoclast differentiation, fusion, attachment, actin ring formation, and activation and that both β3 integrin and osteopontin have an important role in cytoskeletal rearrangements associated with cell attachment and resorption in osteoclasts.
- 社団法人 日本薬理学会の論文
- 2006-03-20
著者
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SUZUKI Keiko
Department of Internal Medicine, Koga General Hospital
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Yamada Shoji
Showa Univ.
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TAKEYAMA Sadaaki
Division of Dental Pharmacology, Department of Oral Biology ; Tohoku University Graduate School of D
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YAMADA Shoji
Department of Dental Pharmacology, School of Dentistry, Showa University
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SAKAI Yasushi
Division of Physiology, School of Nursing and Rehabilitation Sciences, Showa University
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SHINODA Hisashi
Division of Pharmacology, Department of Oral Biology, Tohoku University Graduate School of Dentistry
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Sakai Yasushi
Division Of Physiology School Of Nursing And Rehabilitation Sciences Showa University
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Sakai Yasushi
Division Of Physiology Department Of Occupational Therapy School Of Nursing And Rehabilitation Scien
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Suzuki Keiko
Showa Univ.
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Shinoda Hisashi
Department Of Applied Pharmacology Department Of Oral Biology ; Tohoku University Graduate School Of
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Shinoda Hisashi
Division Of Pharmacology Department Of Oral Biology Tohoku University Graduate School Of Dentistry
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Takeyama Sadaaki
Division Of Dental Pharmacology Department Of Oral Biology ; Tohoku University Graduate School Of De
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Suzuki Keiko
Department Of Internal Medicine Koga General Hospital
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Yamada Shoji
Department Of Dental Pharmacology School Of Dentistry Showa University
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Suzuki Keiko
Deparment Of Cardiology Cenler For Adut Diseases Osaka
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Yamada Shoji
Department of Cellular Neurobiology, Brain Research Institute, Niigata University
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Sakai Yasushi
Division of Bio-Information Engineering, Faculty of Engineering, University of Toyama, Toyama 930-8555, Japan
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