Effect of a new calcium antagonist, nilvadipine, on variant angina pectoris evaluated by 24-hour holter electrocardiography.
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概要
- 論文の詳細を見る
The clinical effect of nilvadipine, a new calcium antagonist, was in-vestigated in a single blind trial in 19 patients with variant angina pectoris. The efficacy of the drug was evaluated on the basis of frequency of anginal attacks and Holier electrocardiographic findings during observation periods and during two treatment periods when the drug was given in doses of 4mg twice a day or 4mg 3 times a day.The frequency of anginal attacks and the consumption of sublingual nitroglycerin tablets decreased significantly in both treatment periods in comparison with those in the observation period before treatment, but in the observation period after treatment tended to increase in comparison with those during the second treatment period.The frequency and duration of ST-segment elevation and the maximum ST-segment elevation confirmed by Holter electrocardiography also improved significantly in both treatment periods, compared with those in the observation period before treatment. Our findings show that nilvadipine is effective for variant angina pectoris at doses of 4mg twice a day.
- International Heart Journal刊行会の論文
著者
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Toyama Seiichi
Department of Cardiology and Cardiac Hemo-dynamics, Center for Adult Diseases.
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Yanaga Takashi
Departent Of Bioclimatology And Medicine Medical Institute Of Bioregulation Kyushu University
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Kishida Hiroshi
Department Of Cardiology Nippon Medical School
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Suzuki Keiko
Deparment Of Cardiology Cenler For Adut Diseases Osaka
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Yanaga Takashi
Department of Bioclimatology and Medicine, Medical Institute of Bioregulation, Kyushu University
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TOYAMA Seiichi
Department of Internal Medicine, the Center for Adult Diseases
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