Vasodilatory Effect of Subsequent Administration of Fasudil, a Rho-Kinase Inhibitor, Surpasses That of Nitroglycerin at the Concentric Coronary Stenosis in Patients With Stable Angina Pectoris
スポンサーリンク
概要
- 論文の詳細を見る
Background Recent studies have suggested that the Rho/Rho-kinase mediated pathway (Rho-kinase pathway) regulates the vasomotion of arteries in pathological conditions. However, it remains unclear regarding whether this pathway regulates the coronary vasomotion of atherosclerotic lesions. Methods and Results The coronary diameter at the concentric stenotic site, which is considered to reflect the whole circumferential atherosclerosis, in patients with stable angina pectoris (SAP; n=11) and the control site in patients with SAP and chest pain syndrome (CPS; n=9), was measured at baseline and after the intracoronary administration of nitroglycerin (200μg) and the subsequent intravenous infusion of fasudil (30mg for 30 min), a Rho-kinase inhibitor, during coronary angiography. The change in the diameter with fasudil at the concentric stenotic site (22.0±10.0%) was significantly higher than that with nitroglycerin (4.1±6.0%, p<0.001) in patients with SAP. Meanwhile, the vasodilatory effect of nitroglycerin and fasudil at the control site was similar in both group of patients (25.5±17.3% and 21.9±14.9% in SAP and 34.4±20.8% and 33.2±23.6% in CPS, respectively). Conclusions The vasodilatory effect of the subsequent administration of fasudil surpassed that of nitroglycerin at the concentric coronary stenosis in patients with SAP, thus suggesting that the Rho-kinase pathway regulates the coronary vasomotion of atherosclerotic lesions.
- 社団法人日本循環器学会の論文
- 2006-03-20
著者
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ATARASHI Hirotsugu
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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TAKANO Teruo
Department of Internal Medicine, Nippon Medical School
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Takano T
Intensive & Cardiac Care Unit Nippon Medical School
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ATARASHI Hirotsugu
Nippon Medical School
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Kishida Hiroshi
Department of Internal Medicine, Nippon Medical School
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Suzuki Takeshi
Department of Internal Medicine, Nippon Medical School
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Takayama Tadateru
Tokyo CCU Network Scientific Committee
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Takano Teruo
Tokyo CCU network Scientific Committee
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Otsuka Toshiaki
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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Ibuki Chikao
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
-
Ishii Kensuke
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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Kodani Eitaro
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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Takano Teruo
日本医科大学附属第二病院 健康管理科
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Kanazawa Hiromi
日本医科大学 内科学第一
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Kanazawa Hiromi
1st Department Of Internal Medicine Nippon Medical School
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Kishida H
Department Of Internal Medicine Division Of Cardiology Nippon Medical School
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Kishida Hiroshi
日本医科大学 循環器内科
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Ibuki Chikao
Department Of Cardiovascular Center Nippon Medical School Chiba-hokusoh Hospital
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Ibuki Chikao
Cardiovascular Center Chiba-hokusoh Hospital Nippon Medical School
-
Ibuki Chikao
Department Of Cardiology Nippon Medical School Tama-nagayama Hospital
-
Takano Teruo
Division Of Cardiology Hepatology Geriatrics And Integrated Medicine Department Of Internal Medicine
-
Kishida Hiroshi
Department Of Internal Medicine Division Of Cardiology Nippon Medical School
-
Ibuki Chikao
Department Of Internal Medicine Chiba-hokusoh Hospital Nippon Medical School
-
Atarashi Hirotsugu
The First Department Of Internal Medicine Nippon Medical School
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Takano Teruo
Department Of 1st. Internal Medicine Nippon Medical School
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Otuka Toshiaki
Department Of Hygiene And Public Health Nippon Medical School
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Kishida Hiroshi
Department Of Cardiology Nippon Medical School Tama-nagayama Hospital
-
Ishii Kensuke
Department Of Internal Medicine Tama-nagayama Hospital Nippon Medical School
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Ishii Kensuke
Department Of Cardiology Nippon Medical School Tama-nagayama Hospital
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Kodani Eitaro
Department Of Internal Medicine And Cardiology Nippon Medical School Tama-nagayama Hospital
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Kodani Eitaro
Department Of Medicine Nippon Medical School Tama-nagayama Hospital
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Kodani Eitaro
Department Of Intenal Medicine Nippon Medical School
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Otsuka Toshiaki
Deparment Of Hygiene And Public Health Nippon Medical School
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ATARASI Hirotsugu
Nippon Medical School
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Takano Teruo
Department Of Lnternal Medicine Nippon Medical School
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Suzuki Takeshi
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Hoshino Kimihiko
First Department Of Internal Medicine Nippon Medical School
-
Atarashi Hirotzugu
The first Department of Nippon Medical School
-
Kishida Hiroshi
Department Of Cardiology Nippon Medical School
-
Kishida Hiroshi
日本医科大学 内科学循環器
-
Kishida Hioroshi
1st Department Of Internal Medicine Nippon Medical School
-
Atarashi Hirotsugu
The First Department Of Internal Medicine Nippon Medical
-
Atarashi Hirotsugu
Department Of Internal Medicine And Cardiology Nippon Medical School Tama-nagayama Hospital
-
Kishida Hiroshi
Division Of Cardiology Hepatology Geriatrics And Integrated Medicine Department Of Internal Medicine
-
Atarashi Hirotsugu
Department Of Cadiology Nippon Medical School Tama-nagayama Hospital
-
Kishida Hiroshi
First Dept.of Intern. Med. Nippon Medical School
-
Ibuki Chikao
Departent Of Cardiology Chiba-hokuso Hospital Nippon Medical School
-
Atarashi Hirotsugu
Dept. Of Intern. Med. Nippon Medical School Tama-nagayama Hosp
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Suzuki Takeshi
Department Of Internal Medicine And Cardiology Tama-nagayama Hospital Nippon Medical School
-
Kodani Eitaro
Department Of Internal Medicine And Cardiology Tama-nagayama Hospital Nippon Medical School
-
Kishida Hiroshi
The 1st Department Of Internal Medicine Nippon Medical School
-
Otsuka Toshiaki
Environmental Medicine Graduate School Of Medicine Nippon Medical School
-
Atarasi Hirotsugu
Department Of Internal Medicine And Cardiology Nippon Medical School Tama-nagayama Hospital
-
Kishida Hiroshi
Division Of Cardiology Hepatology Geriatrics And Integrated Medicine Department Of Internal Medicine
-
Kishida Hiroshi
The 1st Department Of Internal Medicine Nippon Medical School Tokyo
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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