New ECG Criteria for High-Risk Brugada Syndrome

概要

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To identify high-risk patients with Brugada syndrome, the present study reviewed 60 standard 12-lead electro cardiograms from 60 patients collected by the Japanese Brugada syndrome registry. Under blinded conditions, the S wave of lead V_1 was measured from the tip of r to r', and the amplitude of the ST segment in lead V_2 was measured at 0.08 s from the J point. In patients with ventricular fibrillation (n=17), the S wave was significantly longer in V_1 (0.085±0.007 s vs 0.075±0.011 s, p=0.001), and ST segment elevation in V_2 was significantly greater (0.323±0.133mV vs 0.236±0.129mV, p=0.012) than in patients without fibrillation. An S wave width of 0.08 s or more in V_1 had a positive predictive value of 40.5% and negative predictive value of 100% for ventricular fibrillation, with 100% sensitivity. ST elevation of 0.18mV or more in V_2 had a positive predictive value of 37.8% and a negative predictive value of 100% for ventricular fibrillation, with 100% sensitivity. Both an S wave width ≥0.08s in V_1 and ST elevation ≥0.18 mV in V_2 were highly specific indicators of ventricular fibrillation and are proposed as new criteria for high-risk Brugada syndrome.
社団法人日本循環器学会の論文
2002-12-20