Pharmacological Preconditioning With Bradykinin Affords Myocardial Protection Through NO-dependent Mechanisms
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概要
- 論文の詳細を見る
Bradykinin (BK) is one of the triggers of ischemic preconditioning. Protein kinase C (PKC) and mitochondrial ATP-dependent potassium (KATP) channels are central factors in cardioprotection afforded by BK. However, the role of nitric oxide (NO) in the early phase protection of preconditioning with BK is not well understood. We assessed the signaling pathway of the early phase protection of pharmacological preconditioning afforded by BK. Isolated perfused rat hearts (n = 8/group) were subjected to 30-minute global ischemia and 50-minute reperfusion. Left ventricular systolic pressure (LVSP) was recorded prior to the global ischemia and at the end of reperfusion. Preconditioning with BK was induced by two cycles of 5-minute infusion of BK (0.5 μmol/L) and 5-minute washout prior to the global ischemia. To examine participants in the signaling pathway, 5-hydroxydecanoate (5-HD, 200 μmol/L), chelerythrine (CH, 5 μmol/L), or Nω-nitro-L-arginine methyl ester (L-NAME, 50 mmol/L) was added to the perfusate for 5 minutes prior to the infusion of BK. Pharmacological preconditioning by BK improved postischemic recovery of LVSP (+ 45.1% versus control, P < 0.01). Protection by BK was abolished by coadministration of CH, 5-HD, or L-NAME. BK affords myocardial protection in the early phase of pharmacological preconditioning through a pathway that includes endogenous NO, PKC, and mitochondrial KATP channels.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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KUSAMA Yoshiki
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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ATARASHI Hirotsugu
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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YOSHIDA Hiroshi
Department of Clinical Laboratory Medicine, Fukushima Medical College
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Yasutake Masahiro
The First Department of Internal Medicine, Nippon Medical School
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Kishida Hiroshi
The First Department of Internal Medicine, Nippon Medical School
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Takano Teruo
The First Department of Internal Medicine, Nippon Medical School
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Kodani Eitaro
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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Takano Hitoshi
日本医科大学 内科学循環器
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Takano Hitoshi
the First Department of Internal Medicine, Nippon Medical School
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Kusama Yoshiki
Department of Internal Medicine, Nippon Medical School, Tama-Nagayama Hospital
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Kodani Eitaro
Department of Internal Medicine, Nippon Medical School, Tama-Nagayama Hospital
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