Angiographic response to a vasodilating drug, nicorandil, in patients with coronary artery disease.
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the usefulness of nicorandil as an antianginal drug, we compared the coronary vasodilatory response in nonstenotic coronary artery segments and the hemodynamic response in 26 coronary artery disease patients. Both responses were studied prior to sublingual administration of 10mg of this drug and 10, 30 and 60min afterward. The plasma nicorandil concentration was determined up to 120min after administration. The mean coronary dilating ratio of nicorandil was 117% 30min after administration (p<0.01) and showed a good correlation to the plasma nicorandil concentration. The mean maximum dilating ratio of each patient was 125%. There was no difference between individual coronary arteries or between proximal and distal segments in terms of the coronary artery dilating ratio. The plasma nicorandil concentration required for 120% dilation of the coronary arteries was 26ng/ml, 89ng/ml and 142ng/ml for those cases with variant angina, exertional angina and postinfarction angina, respectively. Hemodynamic changes due to administration of this drug included a decrease in blood pressure, and a reduction in total peripheral resistance, rate-pressure product, pulmonary capillary pressure and stroke-work index. These results indicate that the antianginal effects of nicorandil are derived from its coronary vasodilatory action and an inhibitory effect on myocardial oxygen consumption.
- International Heart Journal刊行会の論文
著者
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Takayama Morimasa
Department of 1st internal medicine, Nippon Medical School
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Hata Noritake
Department Of Intensive Care Unit Chiba-hokusoh Hospital Nippon Medical School
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Munakata Kazuo
Department Of Cardiology Internal Medicine Nippon Medical School
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Kusama Yoshiki
Department Of Internal Medicine And Cardiology Nippon Medical School Tama-nagayama Hospital
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Koumi Shin-ichi
Department of Internal Medicine, Nippon Medical School
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Kishida Hiroshi
Department Of Cardiology Nippon Medical School
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Iwahara Shin-ichiro
Department Of Biochemistry And Molecular Biology Nippon Medical School
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Yasutake Masahiro
Department Of Cardiology Nippon Medical School
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SASAKI Yoshimichi
Department of Internal Medicine, Nippon Medical School
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MORI Norikatsu
Department of Internal Medicine, Nippon Medical School
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MUNAKATA Kazuo
Department of Internal Medicine, Nippon Medical School
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IWAHARA Shin-ichiro
Department of Internal Medicine, Nippon Medical School
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