Current Venous Thromboembolism Management and Outcomes in Japan:– Nationwide The Japan Venous Thromboembolism Treatment Registry Observational Study –
スポンサーリンク
概要
- 論文の詳細を見る
Background: Epidemiology and clinical management of acute venous thromboembolism (VTE) are not readily available in Japan. Methods and Results: The Japan VTE Treatment Registry (JAVA) is a multicenter cohort study of consecutive patients with an objectively confirmed, symptomatic acute pulmonary embolism (PE), symptomatic acute deep vein thrombosis (DVT), or asymptomatic acute proximal DVT. Of the 1,076 patients enrolled with acute VTE, 68.7% presented with an isolated DVT; 17.0% had PE alone; and 14.4% had both. VTE management was characterized by a high rate of inferior vena cava filter insertion (40.6%), frequent thrombolysis (21.1%), and sub-therapeutic unfractionated heparin-based anticoagulation, followed by warfarin prescription, mostly targeting an international normalized ratio of 2.0 (range, 1.5–2.5). During a mean observation period of 252.5 days, 29 recurrent cases of VTE were documented, yielding an incidence rate of 3.9 per 100 patient-years. A total of 123 patients died during the study period, corresponding to a rate of 16.6 deaths per 100 patient-years. The incidence of major bleeding was 3.2% per patient-year, including 2 fatal hemorrhages and 7 intracranial hemorrhages. Conclusions: VTE management in Japan is characterized by a highly aggressive strategy in the acute phase, in contrast to protocols that use low-level anticoagulation. The VTE recurrence rates in Japan and Western countries are similar, but mortality is higher in Japan, with significant variability depending on patient and management characteristics.
- 一般社団法人 日本循環器学会の論文
著者
-
Takayama Morimasa
Department of 1st internal medicine, Nippon Medical School
-
Satokawa Hirono
Department Of Cardiovascular Surgery Faculty Of Medicine Fukushima Medical University
-
Unno Naoki
Second Department Of Surgery Hamamatsu University School Of Medicine
-
Komori Kimihiro
Division Of Vascular Surgery Department Of Surgery Nagoya University Graduate School Of Medicine
-
Kojima Tetsuhito
Department Of Internal Medicine Nagoya University School Of Medicine
-
Miyata Tetsuro
Division Of Surgical Oncology And Vascular Surgery Department Of Surgery The University Of Tokyo
-
Nakamura Mashio
Department Of Cardiology And Nephrology Mie University Graduate School Of Medicine
-
Tanabe Nobuhiro
Department Of Chemistry Faculty Of Science Kyoto University
-
Origasa Hideki
Division Of Biostatistics And Clinical Epidemiology University Of Toyama Graduate School Of Medicine
-
Maeda Hideaki
Department Chemistry & Biochemistry Graduate School Of Engineering Kyushu University
-
Yamada Norikazu
Department Of Cardiology And Nephrology Mie University Graduate School Of Medicine
-
Tanemoto Kazuo
Department Of Cardiology Kawasaki Medical School
-
TANEMOTO Kazuo
Department of Cardiovascular Surgery, Kawasaki Medical School
-
Satokawa Hirono
Department of Cardiovascular Surgery, Fukushima Medical University School of Medicine
-
Kojima Tetsuhito
Department of Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University
-
Nakamura Mashio
Department of Clinical Cardiovascular Research, Graduate School of Medicine, Mie University
-
Ozeki Yasushi
Development and Medical Affairs Division, GlaxoSmithKline
-
Shibuya Takashi
Unit of Vascular Surgery, Department of Surgery, Kansai Medical University Hirakata Hospital
-
Kondo Katsuhiro
Clinic of Cardiology, Kokura Memorial Hospital
-
Yamada Norikazu
Department of Cardiology and Nephrology, Graduate School of Medicine, Mie University
関連論文
- PE-152 Quantification of Left Ventricular Mechanical Dyssynchrony in Normal, Hypertrophied, and Dilated Myocardium Quantified by Speckle-Tracking Strain Echocardiography(PE026,Cardiac Function (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scie
- DPJ-028 Impaired Right Ventricular Contraction and Relaxation in Patients with Aortic Stenosis Quantified by Echocardiography Speckle-Tracking Strain and Strain Rate Imaging(DPJ05,Echo/Doppler (Myocardium) (I),Digital Poster Session (Japanese),The 73rd An
- OE-379 Quantification of Left Ventricular Contraction and Relaxation in Patients with Diastolic Heart Failure by Speckle-Tracking Strain and Strain Rate Echocardiography(OE64,Heart Failure (Diagnosis) (M),Oral Presentation (English),The 73rd Annual Scient
- PJ-497 Three-Directional Quantification of Left Ventricular Relaxation Abnormalities in Hypertensive Left Ventricular Hypertrophy with Preserved Systolic Function by Speckle-Tracking Echocardiography(Echo/Doppler(16)(I),Poster Session(Japanese),The 72nd A
- PE-277 Coupling of Left and Right Ventricular Function Stratified by Plasma Brain Natriuretic Peptide Level in Patients with Previous Myocardial Infarction(Cardiac function, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting
- 2 Utility of Yu-Index to Quantify Left Ventricular Systolic and Diastolic Dyssynchrony(Recent Development of Ultrasound Myocardial Imaging,Topic 3 (TP-3) (I),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Activated protein C resistance in the Japanese population due to homozygosity for the factor V R2 haplotype
- PJ-382 Ventilatory Response during Exercise is Less Affected by Chemoreflex Sensitivity in HOCM Patients with Preserved LV Systolic Function(Heart failure, clinical-11, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Prevention of venous thromboembolism according to the guidelines of a domestic manual
- Autologous Peripheral Blood Mononuclear Cell Implantation for Patients With Peripheral Arterial Disease Improves Limb Ischemia
- Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo
- PJ-518 Usefulness of Bare-Metal Stent in the Treatment of Large Coronary Arteries(PJ087,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-347 The Significance of T2-weighted MRI in Early Phase after Percutaneous Transluminal Septal Myocardial Ablation in Patients with Hypertrophic Cardiomyopahty(PJ059,CT/MRI (Myocardium) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- PJ-222 Assessment of the Anatomic Regurgitant Orifice in Aortic Regurgitation by Real-time 3-dimensional Transesophageal Echocardiography(PJ038,Echo/Doppler (New Technology) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-064 Evaluation of Myocardial Damage by Magnetic Resonance Imaging in Patients with Duchenne Muscular Dystrophy(PJ011,CT/MRI (Myocardium) 4 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-345 Concordance of Alcohol Ablation Localization in Interventricular Septum against Systolic Anterior Motion (SAM) of Mitral Valve in HOCM(PE058,Cardiomyopathy/Hypertrophy (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of
- PE-117 Prognostic significance of myocardial SPECT with iodine-123-methyl iodophenyl-pentadecanoic acid (BMIPP) in risk stratification of patients with chronic total coronary occlusion(PE020,Nuclear Cardiology (Coronary, Myocardium) (I),Poster Session (En
- OJ-209 Localization of Mitral Valve Prolapse Affects the Geometry of the Mitral Annulus(OJ35,Valvular Heart Disease/Pericarditis/Cardiac Tumor 1 (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-422 Incidence and Predictors of Appropriate Implantable Cardioverter-Defibrillator Therapies in Patients with Hypertrophic Cardiomyopathy(OE71,ICD (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-292 Mid-term outcomes of medically managed patients with nonrecanalized chronic total coronary artery occlusion(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- 4 Long-term Clinical Follow-up of Patients after Percutaneous Transvenous Mitral Commissurotomy : Single-center Experience over 20 Years(Advances in the Catheter Intervention for Non-coronary Heart Diseases,Topic 5 (TP-5) (M),The 73rd Annual Scientific Me
- 5 Alcohol Septal Ablation for Intra-left Ventricular Obstruction for Drug Refractory Severe Symptoms(Hypertrophic Cardiomyopathy -New Insights into Clinical Course and Management-,ESC-JCS Joint Symposium (ESC-JCS Joint Symposium) (A),The 73rd Annual Scien
- PE-440 The Incidence of Perioperative Complete Atrioventricular Block Associated with Percutaneous Transluminal Septal Myocardial Ablation and the Indication of Permanent Pacemaker(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English)
- Definite diagnosis in Japanese patients with protein C deficiency by identification of causative PROC mutations
- Mutational analysis of SOS1 gene in acute myeloid leukemia
- Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis
- Mutated RAS Induced PLD1 Gene Expression through Increased Sp1 Trascription Factor
- Molecular Defects Associated with Antithrombin Deficiency and Dilated Cardiomyopathy in a Japanese Patient
- Recurrent Mutations of Factor XI Gene in Japanese
- Automated Bedside Measurement of Penile Blood Flow Using Pulse-Volume Plethysmography
- Is There Hemodynamic Rationale for Use of Cuffed Type Anastomosis for Femoro-popliteal Bypass?
- Superficial Thrombophlebitis of the Lower Limbs in Patients with Varicose Veins
- Recurrent Intramural Hematoma of the Small Intestine in a Severe Hemophilia A Patient with a High Titer of Factor VIII Inhibitor : A Case Report and Review of the Literature
- High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation
- PE-538 Human Autologous Bone Marrow-derived Cell Transplantation(BMCT) Combined with Off-pump Coronary Bypass Surgery(OPCAB), Assessment of Feasibility, Mechanisms and Histopathological Findings(Regeneration (angionenesis/myocardial regeneration)-4 (M) PE
- Effect of a portal venous stent for gastrointestinal hemorrhage from jejunal varices caused by portal hypertension after pancreatoduodenectomy
- Clinical Relationship Between Femoral Artery Aneurysms and Arteriomegaly
- Gastrojejunocolic Fistula After Gastrectomy with Billroth II Reconstruction : Report of a Case
- Revascularization to Prevent Postoperative Bowel Infarction After Surgery for Acute Superior Mesenteric Artery Thromboembolism
- Intraoperative Indocyanine Green Fluorescence Lymphography, a Novel Imaging Technique to Detect a Chyle Fistula After an Esophagectomy : Report of a Case
- Laparoscopic Nephrectomy, Ex Vivo Repair, and Autotransplantation for a Renal Artery Aneurysm : Report of a Case
- Venous Thromboembolism : Deep Vein Thrombosis With Pulmonary Embolism, Deep Vein Thrombosis Alone, and Pulmonary Embolism Alone(Hypertension/Pulmonary Circulation)
- PE-282 Management of Ventricular Tachyarrhythmia following PTSMA : Characteristics in Highly Risked HOCM Whom Indicated both PTSMA and ICD-implantation, is PTSMA harmful?(Cardiomyopathy, basic/clinical(04)(M),Poster Session(English),The 72nd Annual Scient
- Study Design of SEASON Registry : Prospective Surveillance of Cardiovascular Events in Antiplatelet-Treated ArterioSclerosis Obliterans Patients in JapaN (SEASON)
- Clinical Outcome and Quality of Life of Octogenarian Patients Following Percutaneous Coronary Intervention or Surgical Coronary Revascularization
- Rate-Responsive Pacemaker Mode Benefits Stroke Rehabilitation Patients with Orthostatic Hypotension : Two Cases of Cardiogenic Cerebral Infarction
- FRS-045 Favorable Occurrence of Procedure Related PTSMA Complication in Consecutive 100 Cases : NMS Single Center Experience(Therapeutic Strategies for Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-448 Evidence for the causative role of oxidative stress in the development of contrast-induced nephropathy in patients with chronic kidney disease.(Kidney/Renal circulation(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japane
- Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation
- Classic Polyarteritis Nodosa Presenting Rare Clinical Manifestations in a Patient with Hemophilia A
- Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond
- Subcutaneous tissue release of amikacin from a fibrin glue/polyurethane graft
- PE-281 Relationship between B-type Natriuretic Peptide Response during Exercise and Functional Capacity in Patients with Hypertrophic Obstructive Cardiomyopathy(Cardiomyopathy, basic/clinical(04)(M),Poster Session(English),The 72nd Annual Scientific Meeti
- 4 Cost Effective Analysis on Percutaneous Alcohol Septal Myocardial Ablation for Drug Refractory Hypertrophic Obstructive Cardiomyopathy : Was Advantage Preserved as Presumed Prediction at the Approval in Government Health Insurance?(Economic Aspects of C
- OE-137 Characteristics of Exercise Induced Abnormal Blood Pressure Response in Patients with Hypertrophic Obstructive Cardiomyopathy(OE23,Heart Failure (Pathophysiology) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- Surgical Management of Abdominal Aortic Aneurysm Associated with Polycystic Kidney Disease : Report of Two Cases
- Successful treatment of pseudoaneurysms of celiac and superior mesenteric arteries by combined endovascular and surgical approach
- Prolapse of Aortic Intimal Flap Into the Left Ventricle : A Rare Cause of Global Myocardial Ischemia in Acute Type A Aortic Dissection
- FRS-115 Improvement of Perfusion is a Predominant Effect of Bone Marrow Transplantation Assessed by Quantitative ECG-gated SPECT(Nuclear Cardiology (I) : FRS14)(Featured Research Session (English))
- Repair of the Aortico-left Ventricular Tunnel Originating from the Right Aortic Sinus with Severe Aortic Valve Regurgitation
- CT Features of Chronic Contained Rupture of an Abdominal Aortic Aneurysm
- A Report of a Surgical Case of Papillary Fibroelastoma in the Left Ventricular Outflow Tract
- Assessment of Cardiac Function after Bone Marrow Transplantation by Quantitative ECG-Gated SPECT
- Cystic Adventitial Disease of the Popliteal Artery : Elongation into the Media of the Popliteal Artery and Communication with the Knee Joint Capsule : Report of a Case
- The Fate of Small Aneurysms of the Internal Iliac Artery Following Proximal Ligation in Abdominal Aortic Aneurysm Repair
- Mechanisms and prevention of intimal thickening of the autogenous vein grafts : possible involvement of nitric oxide
- Signet Ring Cell Carcinoma of the Appendix Manifesting as Colonic Obstruction and Ovarian Tumors : Report of a Case
- Effect of Nasal Continuous Positive Airway Pressure on Pulmonary Edema Complicating Acute Myocardial Infarction
- Do Inferior Vena Cava Filters Reduce the Risk of Acute Pulmonary Embolism in Preoperative Patients with Venous Thromboembolism?
- 1 Results of Open Surgical Repair of Abdominal Aortic Aneurysm(Open surgery or Endovascular Repair for Aortic Aneurysm, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Assessment of Pelvic Hemodynamics During an Open Repair of an Infrarenal Abdominal Aortic Aneurysm
- A Study of Limb Hemodynamics during Hemodialysis
- Adverse Outcome Following Transfemoral Endovascular Stent-Graft Repair of an Abdominal Aortic Aneurysm in a Patient with Severe Liver Dysfunction : Report of a Case
- Successful Surgical Treatment of Aortogastric Fistula After an Esophagectomy and Subsequent Endovascular Graft Placement: Report of a Case
- Foot Blood Volume Measurement in Assessment of Limb Ischemia
- Short-term and long-term outcomes of octogenarians after off-pump coronary artery bypass surgery
- Predictors of Clinical Severity in Post-thrombotic Syndrome
- Evaluation of the Efficacy of Venous Thromboembolism Prophylaxis Guideline Implementation in Japan
- Impact of In Vivo Ranges of the Variances in the Flow Velocity Waveforms and Flow Split Ratio on the Hemodynamic Effects of the Anastomotic Cuff at Distal End-to-Side Anastomosis
- Usefulness of POSSUM Physiological Score for the Estimation of Morbidity and Mortality Risk After Elective Abdominal Aortic Aneurysm Repair in Japan
- Virus-Associated Hemophagocytic Syndrome Caused by Pandemic Swine-Origin Influenza A (H1N1) in a Patient After Unrelated Bone Marrow Transplantation
- リュードカン : その分子構造と機能
- 6 PTSMA for HOCM : Current Understanding(Advances in the Catheter Intervention for Non-coronary Heart Diseases,Topic 5 (TP-5) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Cost disparity between open repair and endovascular aneurysm repair for abdominal aortic aneurysm : a single-institute experience in Japan
- Effects of Calcium Antagonists, Especially Nifedipine, on Variant Angina, Resting Angina, and Unstable Angina
- Infected aortic aneurysm and inflammatory aortic aneurysm-In search of an optimal differential diagnosis
- Eicosapentaenoic Acid as the Gold Standard for Patients With Peripheral Artery Disease? : Subanalysis of the JELIS Trial
- Balanced Mineralization in the Arterial System : Possible Role of Osteoclastogenesis/Osteoblastogenesis in Abdominal Aortic Aneurysm and Stenotic Disease
- Late type III endoleak from fabric tears of a zenith stent graft : report of a case
- Outcomes and Morphologic Changes After Endovascular Repair for Abdominal Aortic Aneurysms With a Severely Angulated Neck:– A Device-Specific Analysis –
- Angiographic response to a vasodilating drug, nicorandil, in patients with coronary artery disease.
- Current Venous Thromboembolism Management and Outcomes in Japan:– Nationwide The Japan Venous Thromboembolism Treatment Registry Observational Study –
- Guidelines for Diagnosis and Treatment of Aortic Aneurysm and Aortic Dissection (JCS 2011) : Digest Version
- Open-stent grafting with a GORE TAG Thoracic Endoprosthesis for an extended severely atheromatous thoracic aortic aneurysm : report of a case
- Management Strategy of Isolated Spontaneous Dissection of the Superior Mesenteric Artery
- Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7
- Outcomes and Morphologic Changes After Endovascular Repair for Abdominal Aortic Aneurysms With a Severely Angulated Neck : A Device-Specific Analysis
- Chest-Compression-Only Bystander Cardiopulmonary Resuscitation in the 30:2 Compression-to-Ventilation Ratio Era : Nationwide Observational Study
- Role of down-regulated neutral ceramidase during all-trans retinoic acid-induced neuronal differentiation in SH-SY5Y neuroblastoma cells
- Detection of hepatocellular carcinomas with near-infrared fluorescence imaging using indocyanine green : its usefulness and limitation