Autologous Peripheral Blood Mononuclear Cell Implantation for Patients With Peripheral Arterial Disease Improves Limb Ischemia
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概要
- 論文の詳細を見る
Background Implantation of bone marrow mononuclear cells, including endothelial progenitor cells, into ischemic limbs has been shown to improve collateral vessel formation. In the present study the safety and feasibility of autologous peripheral blood mononuclear cells (PBMNCs) implantation after granulocyte-colony stimulating factor (G-CSF)-induced mobilization was investigated in patients with severe peripheral arterial disease. Methods and Results Six cases were enrolled : 5 of thromboangitis obliterans and 1 of arteriosclerosis obliterans. Following administration of G-CSF (10μg・kg^<-1>・day^<-1>), PBMNCs were harvested and injected intramuscularly (5 legs and 1 arm) for 2 days for the patients with ischemia of the legs. No serious adverse events related to G-CSF administration, harvest or implantation were observed during this study period. Improvement in the ankle-brachial pressure index (ΔABI : >0.1) was seen in 4 patients at 4 weeks and ischemic ulcers improved in 3 of 3 patients. The mean maximum walking distance significantly increased from 203m to 559m (p=0.031) at 4 weeks and was sustained for 24 weeks. Significant improvement was seen in physiological functioning subscale of Short Form-36. Conclusion Implantation of PBMNCs collected after G-CSF administration could be an alternative to therapeutic angioplasty in patients with severe peripheral arterial disease.
- 社団法人日本循環器学会の論文
- 2005-09-20
著者
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OHYA Yusuke
University of the Ryukyus
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HIGASHIUESATO Yasushi
Department of Cardiovascular Medicine, Nephrology and Neurology University of the Ryukyus
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Higashiuesato Yasushi
Department Of Cardiovascular Medicine Nephrology And Neurology University Of The Ryukyus
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Ishida Akio
Division of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of M
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Ohya Yusuke
Division of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of M
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Sakuda Hitoshi
Second Department of Surgery, University of the Ryukyus School of Medicine
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Ohshiro Katsuhiko
Division of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of M
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Nakaema Moriyasu
Second Department of Surgery, University of the Ryukyus School of Medicine
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Matsubara Shinobu
Second Department of Surgery, University of the Ryukyus School of Medicine
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Yakabi Shizuko
Blood Transfusion Department, University of the Ryukyus School of Medicine
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Kakihana Ayano
Division of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of M
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Ueda Mika
Division of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of M
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Miyagi Chiharu
Division of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of M
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Yamane Nobuhisa
Blood Transfusion Department, University of the Ryukyus School of Medicine
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Koja Kageharu
Second Department of Surgery, University of the Ryukyus School of Medicine
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Komori Kimihiro
Division of Vascular Surgery, Department of Surgery, Nagoya University, Graduate School of Medicine
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Takishita Shuichi
Division of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of M
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Kakihana Ayano
Division Of Cardiovascular Medicine Nephrology And Neurology University Of The Ryukyus School Of Med
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Ishida Akio
Department Of Cardiovascular Medicine Nephrology And Neurology
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Saruta Takao
Dept. Of Internal Medicine Keio University School Of Medicine
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Sakuda Hitoshi
Second Department Of Surgery Faculty Of Medicine University Of The Ryukyus
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Koja Kageharu
Second Department Of Surgery Faculty Of Medicine University Of The Ryukyus
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Koja Kageharu
Second Department Of Surgery University Of The Ryukyus School Of Medicine
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Sakuda Hitoshi
Thoracic And Cardiovascular Surgery Department Of Bioregulatory Medicine Faculty Of Medicine Univers
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Komori Kimihiro
Division Of Vascular Surgery Department Of Surgery Nagoya University Graduate School Of Medicine
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Takishita Shuichi
Department Of Molecular Cardiology Osaka University Graduate School Of Medicine
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Okubo Yasuhiro
Department Of Geriatric Medicine University Of Tokyo
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Ishida Akio
The Third Department Of Internal Medicine University Of The Ryukyus
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Ueda Mika
Division Of Cardiovascular Medicine Nephrology And Neurology University Of The Ryukyus School Of Med
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Yakabi Shizuko
Blood Transfusion Department University Of The Ryukyus School Of Medicine
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Miyagi Chiharu
Division Of Cardiovascular Medicine Nephrology And Neurology University Of The Ryukyus School Of Med
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Matsubara Shinobu
Thoracic And Cardiovascular Surgery Department Of Bioregulatory Medicine Faculty Of Medicine Univers
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Nakaema Moriyasu
Department Of Cardiovascular Medicine Nephrology And Neurology School Of Medicine University Of The
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Ouchi Yasuyoshi
Department Of Geriatric Medicine Graduate School Of Medicine And Faculty Of Medicine The University
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Nakamoto Minori
Department Of Cardiovascular Medicine Nephrology And Neurology School Of Medicine University Of The
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Higashiuesato Yasushi
The Third Department Of Internal Medicine University Of The Ryukyus
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Yamane Nobuhisa
Blood Transfusion Department University Of The Ryukyus School Of Medicine
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Ohshiro Katsuhiko
Division Of Cardiovascular Medicine Nephrology And Neurology University Of The Ryukyus School Of Med
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Ohya Yusuke
Department Of Cardiovascular Medicine Nephrology And Neurology School Of Medicine University Of The
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Takishita Shuichi
Division Of Cardiology Department Of Medicine Kohka Public Hospital
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