EFFECTS OF POLYAMINES ON THE CENTRAL NERVOUS SYSTEM
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概要
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Effects of polyamines on the central nervous system were studied in mice. Intraperitoneal administration of Spermidine (SPD) and Spermine (SPM) decreased spontaneous motor activity as measured by either the photo-cell counters method or the open-field test and lowered rectal temperature. A significant prolongation of sleeping time after pentobarbital was confirmed in small doses of SPD and SPM which had slight influence on spontaneous motor activity. The time to convulsion and death induced by strychnine was elongated by SPD and SPM. SPM in small doses inhibited writhing responses induced by 0.7% acetic acid. In addition, methamphetamine-induced hyperactivity and conditioned avoidance response were blocked by SPM in doses which decreased spontaneous motor activity. In all experiments, SPM appeared to have a powerful pharmacological activity compared with SPD. LD50 for SPD and SPM was 620 (500-769) mg/kg i.p. and 310 (200-480) mg kg i.p., respectively.
- 社団法人 日本薬理学会の論文
著者
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Sakurada Tsukasa
Department Of Biochemistry Daiichi College Of Pharmaceutical Sciences
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Sakurada T
Daiichi Coll. Pharmaceutical Sci. Fukuoka
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Sato Takumi
東北薬科大学 薬理
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Tadano Takeshi
Department Of Pharmacology Tohoku College Of Pharmacy
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Onodera Kenji
Department Of Dental Pharmacology
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Kisara Kensuke
Department Of Pharmacology Tohoku College Of Pharmacy
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KISARA Kensuke
Department of Chemical Pharmacology Tohoku College of Pharmacy
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TADANO Takeshi
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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SAKURADA Tsukasa
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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ONODERA Kenji
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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