Regional changes in brain histamine levels following dietary-induced thiamine deficiency in rats.
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概要
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Histamine levels in thiamine deficient rats were significantly lower in the hippocampus, amygdala, olfactory bulb, thalamus and pons-medulla oblongata than those of normal and pair-fed groups. In the case of the hypothalamus, thiamine deficiency produced a significant increase in histamine levels. These changes observed in the thiamine deficient group were reversed to the normal levels by supplying the normal diet. These data present a new finding that thiamine deficiency affects the central histaminergic neuron system as well as other monoaminergic systems.
- 公益社団法人 日本薬理学会の論文
著者
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Maeyama Kazutaka
Department Of Pharmacology Ehime University School Of Medicine
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Watanabe Takehiko
Department Of Mechanical Engineering Niigata University
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WATANABE Takehiko
Department of Pharmacology, Tohoku University School of Medicine
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ONODERA Kenji
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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MAEYAMA Kazutaka
Department of Pharmacology, Tohoku University School of Medicine
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