The Release and Subsequent Synthesis of Histamine in a Transfected Subclone of Rat Basophilic Leukemia Cells That Expresses Human Muscarinic ml Receptors
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概要
- 論文の詳細を見る
Effects of carbachol and antigen (dinitrophenylated bovine serum albumin) on histamine release and histidine decarboxylase (HDC, the enzyme synthesizing histamine) activity were studied in 2H3-ml cells, a subclone of rat basophilic leukemia cells that expresses human muscarinic ml receptors through transfection with the gene. Carbachol stimulated the release of histamine and the activity of HDC with 30-50% the intensity of the maximal effect of the antigen. Pirenzepine, an ml antagonist, inhibited these carbachol effects in a dose-dependent manner. The effect of the combination of carbachol and antigen on histamine release showed no additivity. These results indicate that these effects of carbachol are exerted via ml receptors, and they suggest that the actions of carbachol and antigen on histamine release share a common pathway(s), and the release and synthesis of histamine have a positive relationship like in a feedback system.
- 社団法人 日本薬理学会の論文
- 1995-10-01
著者
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Goto Y
National Cardiovascular Center Suita Jpn
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Goto Yoshinori
Department Of Materials Science And Engineering Yamagata University
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MAEYAMA Kazutaka
Department of Pharmacology, Ehime University School of Medicine
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Maeyama K
Ehime Univ. School Of Medicine Ehime Jpn
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Maeyama Kazutaka
Department Of Pharmacology Ehime University School Of Medicine
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