Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats
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概要
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Sleep deprivation induces several negative effects on behavior, emotion, attention, and learning ability. Sleep appears to be particularly important during adolescent brain development. In the present study, we examined the effects of sleep deprivation on behavior and hypothalamic neurotransmission including histamine and orexin neurons in adolescent rats using the treadmill method. Adolescent male rats were divided into three groups: treadmill sleep-deprived, treadmill control, and cage control groups. Energy expenditure, anxiety-like behavior, and locomotor activity were examined among the three groups. Histamine concentration in the cortex and diencephalon and the number of c-Fos–positive neurons in the hypothalamus were also examined. In addition, histamine and orexin neurons in the hypothalamus were simultaneously identified using rat histidine decarboxylase and orexin-A immunohistochemistry, respectively. Both energy expenditure and anxiety-related behavior significantly increased by the experimental 3-day sleep deprivation, while exploratory locomotor activity significantly decreased. Histamine contents did not change in the cortex, but significantly decreased in the diencephalon of sleep-deprived rats. Increased expression of c-Fos–positive neurons, including subgroup histamine and orexin neurons, was observed in the hypothalamus. These findings indicate that sleep deprivation increases energy expenditure and anxiety in adolescent rats and provide evidence for the pivotal role of hypothalamus subgroup histamine and orexin neurons in the behavioral response to sleep deprivation.
- 社団法人 日本薬理学会の論文
著者
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Sakurai Eiko
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Zhang Dongying
Department Of Pharmacology Tohoku University School Of Medicine
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Yanai Kazuhiko
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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WATANABE Takehiko
Department of Pharmacology, Tohoku University Graduate School of Medicine
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Yoshikawa Takeo
Department Of Pharmacology Tohoku University School Of Medicine
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Okamura Nobuyuki
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Zhang Jian
Department Of Cardiology Rui Jin Hospital Shanghai Jiao Tong University School Of Medicine
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Sakurai Eiichi
Aomori University
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XU Ajing
Department of Pharmacology, Tohoku University School of Medicine
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KURAMASU Atsuo
Department of Pharmacology, Tohoku University School of Medicine
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Sakurai E
Dep. Of Pharmacology Tohoku Univ. Graduate School Of Medicine
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Li Jiyu
Department of Pharmacology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, China
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Xu Ajing
Department Of Pharmacology Xinhua Hospital School Of Medicine Shanghai Jiaotong University
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Sakurai Eiko
Department Of Pharmacology Tohoku University School Of Medicine
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Watanabe Takehiko
Department Of Pharmacology Ii Institute Of Higher Nervous Activity Osaka University School Of Medici
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Li Jiyu
Department Of Pharmacology Xinhua Hospital School Of Medicine Shanghai Jiaotong University
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Zhang Jian
Department Of Biology Huaihua College
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Watanabe Takehiko
Department Of Mechanical Engineering Niigata University
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Kuramasu Atsuo
Department Of Pharmacology Tohoku University School Of Medicine
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