Relationship Between Effects of Alcohol on Psychomotor Performances and Blood Alcohol Concentrations
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概要
- 論文の詳細を見る
Ethanol is a social drug and has been generally known to be a CNS depressant.A large fluctuation of blood alcohol concentration(BAC)is well−known to occur due to main factors such as the genetic polymorphism of the main alcohol metabolizing enzymes and the effect of blood.Few studies have substantially discussed the relationship between impaired CNS activities and BAC.In this study, focusing on the correlation of BAC, we investigated the acute effects of alcohol intake on cognitive performance in humans by objective evaluation methods consisting of the attention−demanding cognitive tasks.Tasks were administered to ten healthy male volunteers before and after ingesting established amounts of alcohol.With increased BAC, we observed prolongation of reaction time performances and lowering of a coordination performance.From the results, we concluded that cognitive performance deteriorates with an increase of BAC.Additionally, the BAC threshold that causes significant impairment of cognitive performance was estimated to be approximately 50 mg/dl(ca.10 mM).
- 社団法人 日本薬理学会の論文
- 2000-07-01
著者
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Katayama Y
Department Of Neurology Nephrology And Rheumatology Nippon Medical School
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YANAI Kazuhiko
Department of Pharmacology, Tohoku University Graduate School of Medicine
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Yamaguchi K
Division Of Nuclear Medicine Cyclotron Radioisotope Center Tohoku University
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ITOH Masatoshi
Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University
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SAKURAI Eiko
Department of Pharmacology, Tohoku University, Graduate School of Medicine
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Sakurai Eiko
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Itoh M
Division Of Cyclotron Nuclear Medicine Cyclotron And Radioisotope Center Tohoku University
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Yanai K
Division Of Cyclotron Nuclear Medicine Cyclotron And Radioisotope Center Tohoku University
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Yanai Kazuhiko
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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KANO MICHIKO
Department of Respiratory Medicine and Anesthesiology, Shiogama City Hospital
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WATANABE Takehiko
Department of Pharmacology, Tohoku University Graduate School of Medicine
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Itoh Masatoshi
Division Of Cyclotron Nuclear Medicine Cyclotron And Radioisotope Center Tohoku University
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Okamura Nobuyuki
Department Of Pharmacology Tohoku University School Of Medicine
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Okamura Nobuyuki
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Kano Michiko
Department Of Pharmacology Tohoku University School Of Medicine
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Sakurai Eiichi
Department Of Pharmaceutics I Tohoku College Of Pharmacy
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Sakurai Eiichi
Aomori University
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Okamura N
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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TAGAWA Masaaki
Department of Pharmacology, Tohoku University School of Medicine
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OKAMURA Nobuyuki
Division of Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University
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Sakurai E
Dep. Of Pharmacology Tohoku Univ. Graduate School Of Medicine
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Itoh Masatoshi
Division Of Nuclear Medicine Cyclotron And Radioisotope Center Tohoku University
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Tagawa Masaaki
Department Of Pharmacology Tohoku University School Of Medicine
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Watanabe T
東北大学 医系研究 細胞薬理
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Sakurai Eiko
Department Of Pharmacology Tohoku University School Of Medicine
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Watanabe Takehiko
Department Of Pharmacology Ii Institute Of Higher Nervous Activity Osaka University School Of Medici
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Kano Michiko
Department Of Behavioral Medicine Tohoku University Graduate School Of Medicine
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Watanabe Takehiko
Department Of Mechanical Engineering Niigata University
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Sakurai Eiko
Department of Pharmacology I, Tohoku University School of Medicine
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Yanai Kazuhiko
Department of Pharmacology I, Tohoku University School of Medicine
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