Dissolution Profiles of Principal Ingredients in Kampo Medicinal Powders by High-Performance Liquid Chromatography
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概要
- 論文の詳細を見る
We describe here a method using HPLC for the simultaneous determination of albiflorin, paeoniflorin, glycyrrhizin and six flavanone glycosides (liquiritin, liquiritin apioside, naringin, neohesperidin, hesperidin and narirutin) in the Kampo medicines, Shigyaku-san and Haino-san. All nine components were separated in less than 40 min by linear gradient elution using a mobile phase containing aqueous phosphoric acid and acetonitrile. The dissolution of these components from powders of Shigyaku-san in aqueous solution at pH 1.80,4.08 and 6.89 was examined. All of the components except glycyrrhizin were dissolved entirely within 5 min regardless of pH. Dissolution of glycyrrhizin was dependent on the pH of the aqueous solution, and increased with increasing pH.
- 社団法人日本薬学会の論文
- 2000-11-01
著者
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Onishi Yuka
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Onishi Yuka
福山大学 薬
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OKAMURA Nobuyuki
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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YAGI Akira
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Tsuruta Yasuto
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Yagi A
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Yagi Akira
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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MAKI Tomonori
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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ISHIDA Sachie
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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URAGUCHI Chie
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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SADASUE Etsuko
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Okamura Nobuyuki
Department Of Pharmacology Tohoku University School Of Medicine
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Okamura Nobuyuki
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Okamura Nobuyuki
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Okamura Nobuyuki
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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Ishida Sachie
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Uraguchi Chie
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Maki T
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Sadasue Etsuko
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tsuruta Y
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tsuruta Yasuto
Faculty Of Pharmaceutical Sciences Kyushu University
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Okamura N
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Yagi Akira
Faculty Of Pharmaceutical Sciences Kyushu University
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