Effect of cyclo (trans-4-L-hydroxyprolyl-L-serine) from hydrolysate of human placenta on baby hamster kidney -21/C-13 cells
スポンサーリンク
概要
- 論文の詳細を見る
A dipeptide isolated from the hydrolysate of human placenta in a yield of 0.011 % and identified as cyclo (trans-4-L-Hydroxyprolyl-L-Serine) on the basis of physico-chemical and HPLC examination showed a proliferation-promoting activity (% control: 133) on baby hamster kidney-21/C-13 cells at a dose of 12.5 μg/ml. From the hydrolysate uracil was also isolated in a yield of 0.009 % and it also showed the proliferation-promoting activity (% control : 130) at a dose of 12.5 μg/ml. Synthesis of the cyclic dipeptide was performed by a modified method of Nitecki.
- 日本生薬学会の論文
- 1998-04-20
著者
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Ishizu T
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Iitsuka Tadashi
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
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YAGI Akira
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Ishizu Takashi
Department Of Nephrology Tsukuba Central Hospital
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Okamura Nobuyuki
Department Of Pharmacology Tohoku University School Of Medicine
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Okamura Nobuyuki
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Okamura N
Department Of Pharmacology Tohoku University Graduate School Of Medicine
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Yagi Akira
Faculty Of Pharmaceutical Sciences Kyushu University
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Shida Takao
Japan Allergy And Asthma Clinic
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Itoh Hiroshi
Maruzen Pharmaceutical Co. Ltd.
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Shida T
Japan Clinical Research Institute For Allergic Diseases
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