Simultaneous Determination of Glycyrrhizin Metabolites Formed by the Incubation of Glycyrrhizin with Rat Feces by Semi-micro High-Performance Liquid Chromatography

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概要

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• A method for semi-micro high-performance liquid chromatography (HPLC) has been established for the simultaneous determination of 3α-hydroxyglycyrrhetic acid and 3-dehydroglycyrrhetic acid together with glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide formed by incubation of glycyrrhizin with rat feces. The analysis was accomplished within 25min with a TSKgel ODS-80TsQA (150×2.0mm I.d.) column by linear gradient elution using a mobile phase containing aqueous phosphoric acid and acetonitrile at a flow rate of 0.2 ml-min^1, a thermostatic oven at 25℃, and detection at 254 nm. The detection limits of these com-pounds were O.lpmol per injection (5 μI). The metabolites of glycyrrhizin, by anaerobic or aerobic incubation with rat fecal suspension over 48 h, were determined. Glycyrrhizin was almost completely converted to metabolite glycyrrhetic acid, and metabolites 3α-hydroxyglycyrrhetic acid and 3-dehydroglycyrrhetic acid in negligible amounts in anaerobic conditions. However, the metabolic time courses of 3-dehydroglycyrrhetic acid when incubated in aerobic conditions revealed that it apparently continued increasing during the whole incubation period.

• 社団法人日本薬学会の論文
• 2003-05-01

著者

• Ishizu T

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Iitsuka Tadashi

  Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba

• OKAMURA Nobuyuki

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• MIYAUCHI Hidetoshi

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• CHOSHI Tominari

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• ISHIZU Takashi

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• YAGI Akira

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Yagi Akira

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Ishizu Takashi

  Department Of Nephrology Tsukuba Central Hospital

• Ishizu Takashi

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Choshi Tominari

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Miyauchi Hidetoshi

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Okamura Nobuyuki

  Department Of Pharmacology Tohoku University School Of Medicine

• Okamura Nobuyuki

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Okamura Nobuyuki

  Department Of Pharmacology Tohoku University Graduate School Of Medicine

• Okamura Nobuyuki

  Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University

• Choshi T

  Fukuyama Univ. Hiroshima Jpn

• Okamura N

  Department Of Pharmacology Tohoku University Graduate School Of Medicine

• Yagi Akira

  Faculty Of Pharmaceutical Sciences Kyushu University

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