Quantum Chemical Study for Radical-Induced DNA Effects and Damage

スポンサーリンク

概要

• 論文の詳細を見る

• Differences in molecular interaction between bases (adenine (A), guanine (G), and cytosine (C)) and the methyl (Me)-radical were investigated by perturbation analysis using the quantum chemical method. Part of the source of damage to the DNA was elucidated at the molecular level. In the reaction of each of the saccharide derivatives (dA, dG, and dC) with Me-radical, the reactivity of dG (≈dA) is more than about 10 times larger than that of dC. Therefore, it is expected that the base G (and A) was more than about 10 times than the base C in radical-reactivity of the base. For the reaction of dA and dG with the radical, the C8 site of the partial purine ring of dA and dG, and the C5 site of the pyrimidine ring of dC were the main reaction sites for methylation. In the reaction of DNA composed of hydrogen-bonded base pairs G-C and A-T with the radical, the purine ring in the constituent base G reacted preferentially with the radical to yield 8-methyl-guanines.

• 公益社団法人 日本薬学会の論文

著者

• Tsutsumi Hiroyuki

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Ishizu Takashi

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Niiya Tokihiro

  Nii Bio-plant Research Institute in a Limited Company

• Kimura Masahiko

  Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University

• Ono Nobufumi

  Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University

関連論文

• Stereochemical structure and intermolecular interaction of complexes of (-)-gallocatechin-3-O-gallate and caffeine
• Simultaneous Determination of Glycyrrhizin Metabolites Formed by the Incubation of Glycyrrhizin with Rat Feces by Semi-micro High-Performance Liquid Chromatography
• Offset π–π Interaction in Crystal Structure of (−)-Gallocatechin-3-O-gallate
• Crystal Structure of Complex of Gallocatechin Gallate and Caffeine
• Stereochemical Structure and Intermolecular Interaction of Complexes of (−)-Gallocatechin-3-O-gallate and Caffeine
• Selective Preparation of Substituted Maltooligosaccharides through Enzymatic Hydrolysis of Substituted β-Cyclodextrins by Bacterial α-Amylase (Saccharifying Type). A Novel Method for Determining Regiochemical Structure of Disubstituted β-Cyclodextrin
• Indonesian Medicinal Plants. XXIV. Stereochemical Structure of Perseitol・K^+ Complex Isolated from the Leaves of Scurrula fusca(Loranthaceae)
• Dibridged Bis(Zn^-cyclen) : A Novel Host Molecule of Malonate Dianion in Aqueous Solution
• Stereochemical Structure Determination of Caffeine Complexes with Galloylated and Non-galloylated Catechins
• Solution Conformation of Ginseng Tetrapeptide H-L-Val-γ-D-Glu-D-Arg-Gly-OH
• Enantimer-Differentiating Ability of Cyclo(Phe-Pro)_4 for Noradrenaline Hydrochloride and Preparation of Complexes with Various Amine Hydrochlorides
• Enantiomer-Differentiating Ability of Cyclo(L-Phe-L-Pro)_4 Having a Rigid Skeleton for Phenylalanine Methylester Hydrochloride
• Enantiomer-differentiating Ability of Cyclo (L-Phe-L-Pro)_4
• Configurational Studies of Complexes of Various Tea Catechins and Caffeine in Crystal State
• Characterization of Creaming Precipitate of Tea Catechins and Caffeine in Aqueous Solution
• Drug Development for Eradication with InclusionComplex of Multifunctional-modified.BETA.CD
• The Influence of Rhein 8-O-β-D-Glucopyranoside on the Purgative Action of Sennoside A from Rhubarb in Mice
• Quantum Chemical Study for Radical-Induced DNA Effects and Damage
• Stereochemical Structure of the Complex of (-)-Epigallocatechin 3-Gallate and Caffeine
• Drug Development for Eradication with Inclusion Complex of Multifunctional-modifiedβCD
• Influence of Novel Supramolecular Substance, [2] Rotaxane, on the Caspase Signaling Pathway in Melanoma and Colon Cancer Cells In Vitro

もっと見る 閉じる

スポンサーリンク