Influence of Novel Supramolecular Substance, [2] Rotaxane, on the Caspase Signaling Pathway in Melanoma and Colon Cancer Cells In Vitro

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概要

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• We studied the influence of novel supramolecular substance, [2] rotaxane (TRO-A0001), on caspase signaling and cell viability in cancer cell lines. TRO-A0001 suppressed concentration-dependently cell proliferation. Expression of the cleaved-form caspase-3 and PARP was significantly increased in cells exposed to TRO-A0001. The expression of Bax was increased by TRO-A0001. Furthermore, the down-regulation of Bax by siRNA resulted in growth activation significantly. The morphological analysis demonstrated that TRO-A0001 increased the levels of apoptotic cells in human cancer cell lines. These results suggest that TRO-A0001 induces apoptosis in cancer cells and holds potential as a new anti-tumor medicine.

著者

• Nishio Kazuto

  Department Of Genome Biology Kinki University School Of Medicine

• Takata Toshikazu

  Department Of Applied Chemistry Graduate School Of Engineering Osaka Prefecture University

• FUJITA Yoshihiko

  Department of Anatomy (1st Division), Kinki University School of Medicine

• Kimura Masahiko

  Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University

• Ono Nobufumi

  Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University

• Nishio Kazuto

  Department of Genome Biology, Kinki University School of Medicine, Japan

• Hara Kazuki

  Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

• Beppu Tatsuya

  Medicinal Informatics and Research Unit, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

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