Efficacy of Edaravone, a Free Radical Scavenger, for the Treatment of Acute Lacunar Infarction
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概要
- 論文の詳細を見る
The effect of edaravone as an inhibitor of ischemic brain damage in addition to routine treatment was retrospectively examined in 70 patients with lacunar infarction who were admitted within 24 hours of symptom onset. Clinical status was assessed using the National Institutes of Health Stroke Scale (NIHSS). The modified Rankin Scale (MRS) was used to assess clinical outcomes at 3 months after onset, with a good outcome defined as MRS score ≦2. Risk factors were also evaluated, including evidence of hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease, and a history of smoking longer than 2 months. The probability of a good outcome and independence at 3 months was assessed by backward stepwise logistic regression analysis based on the maximum likelihood ratio. Administration of edaravone yielded an odds ratio with multivariate adjustment of 6.49 (95% confidence interval, 1.35 to 50.32 ; p < 0.05) for a good outcome at 3 months. Higher baseline NIHSS score and higher age also adversely affected the outcome at 3 months (p < 0.005). Administration of edaravone improves the outcome of patients with lacunar infarction.
- 日本脳神経外科学会の論文
- 2005-07-15
著者
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Katayama Y
Department Of Neurology Nephrology And Rheumatology Nippon Medical School
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TERAMOTO Akira
The Department of Neurosurgery, Nephrology and Rheumatology, Nippon Medical School
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KATAYAMA Yasuo
The Second Department of Internal Medicine, Nippon Medical School
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MISHINA Masahiro
The Department of Neurology, Neurological Institute
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KOMABA Yuichi
The Department of Neurology, Neurological Institute
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KOBAYASHI Shiro
The Department of Neurosurgery, Neurological Institute
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TANAKA Nobuyuki
The Department of Neurology, Neurological Institute
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KOMINAMI Shushi
The Department of Neurosurgery, Neurological Institute
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FUKUCHI Takaharu
The Department of Neurology, Neurological Institute
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MIZUNARI Takayuki
The Department of Neurosurgery, Neurological Institute
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HAMAMOTO Makoto
The Department of Internal Medicine, Nippon Medical School Chiba-Hokusoh Hospital
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Kimura Y
Molecular Imaging Center National Institute Of Radiological Sciences
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Kimura Yuichi
国立循環器病センター研究所 放射線医学部
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Mishina Masahiro
Positron Medical Center Tokyo Metropolitan Institute Of Gerontology
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Mishina Masahiro
東京都老人総合研究所ポジトロン医学研究施設
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Mishina Masahiro
日本医科大学千葉北総病院 神経内科
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Mishina Masahiro
放射線医学総合研究所分子イメージング研究センター 先端生体計測研究グループ
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Mizuno Masaki
早稲田大学 人間科学研究科
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Katayama Yasuo
日本医科大学 内科学第2
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Teramoto Akira
Department Of Neurosurgery Nippon Medical School
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Komaba Yuichi
Molecular Imaging Center National Institute Of Radiological Sciences
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Mizuno Masaki
Faculty Of Sport Sciences Waseda University
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Katayama Yasuo
The Second Department Of Internal Medicine Nippon Medical School
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Komaba Yuichi
The Second Department Of Internal Medicine Nippon Medical School
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Teramoto Akira
The Department Of Neurosurgery Nephrology And Rheumatology Nippon Medical School
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Fukuchi Takaharu
Neurological Institute Nippon Medical School Chiba-hokusoh Hospital
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Kimura Yasuyuki
Osaka University Graduate School Of Medicine
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Kimura Yuichi
Molecular Imaging Center National Institute Of Radiological Sciences
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Kominami Shushi
Department Of Neurosurgery Chiba Hokusoh Hospital Nippon Medical School
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Kobayashi Shiro
Department Of Neurosurgery Neurological Institute Chiba Hokuso Hospital Nippon Medical School
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Kobayashi Shiro
Department Of Neurosurgery Chiba Hokuso Hospital Nippon Medical School
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Kitamura Shin
The Second Department Of Internal Medicine Nippon Medical School
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Mizunari Takayuki
Department Of Neurosurgery. Neurosurgical Institute Chiba Hokuso Hospital Nippon Medical School
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Kobayashi Shiro
Department Of Neurosurgery Nippon Medical School
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Hamamoto Makoto
The Department Of Internal Medicine Nippon Medical School Chiba-hokusoh Hospital
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