Molecular Cloning and Characterization of Rat Semicarbazide-Sensitive Amine Oxidase(Biochemistry/Molecular Biology)

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概要

• 論文の詳細を見る

• Semicarbazide-sensitive amine oxidase (SSAO)(EC 1.4.3.6) is widely distributed in nature and catalyzes the oxidative deamination of primary amines. Although SSAO full-length cDNA squences have been reported for some mammalian species, only a partial 5'-terminal sequence has been confirmed in the rat. In this study we isolated full-length SSAO cDNA from rat aorta and examined its mRNA expression in various rat tissues by real-time PCR, as well as the subcellular and tissue distributions of SSAO activity. The deduced amino acid sequence showed 91% and 80% identity with mouse and human SSAO, respectively. The mRNA was expressed in many rat tissues. Those findings were supported by the broad distribution of SSAO in the body. Thus, a high level of SSAO was shown in adipocytes by both mRNA expression and enzyme activity measurement. The results suggest that SSAO may play an important role in the degradation of biologically active amines in adipocytes.

• 公益社団法人日本薬学会の論文
• 2005-03-01

著者

• Tanaka Y

  Kyushu Univ. Fukuoka Jpn

• Ochiai Yoshinori

  Deparetment of Gene Diagnositics and Theraputics, Resarch Institute, International Medical Center of

• Ochiai Yoshinori

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Itoh K

  Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G

• Itoh Kunio

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Sakurai Eiichi

  Department Of Pharmaceutics I Tohoku College Of Pharmacy

• Sakurai Eiichi

  Aomori University

• Tanaka Y

  Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn

• Tanaka Yorihisa

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Ochiai Yuta

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Sakurai E

  Dep. Of Pharmacology Tohoku Univ. Graduate School Of Medicine

• Tanaka Yorihisa

  Department Of Applied Chemistry National Defense Academy

• Sakurai Eiko

  Department Of Pharmacology Tohoku University School Of Medicine

• Tanaka Yoshitaka

  Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University

• Itoh Kunio

  Department of Biopharmaceutics, Tohoku Pharmaceutical University

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