Effects of Selenium Deficiency on Aldehyde Oxidase 1 in Rats(Molecular and Cell Biology)

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概要

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• Selenium deficiency has been reported to result in an extraordinary decrease of glutathione peroxidase (GSH-Px) and, reversely, an increase of detoxifying enzymes such as glutathione-S-transferase (GST), uridine-5'-diphosphate glucuronosyltransferase (UGT), nicotinamide-dependent quinine oxidoreductase (NQO1; DT-diaphorase), and epoxide hydrolase without significantly affecting cytochrome P450 activity. However, little is known about the effects on aldehyde oxidase 1 (AOX1) activity towards various kinds of aldehydes and N-heterocyclic aromatic compounds. The aim of this study is to clarify the effects of selenium deficiency on AOX1 in rats. As expected, selenium deficiency was confirmed by the extremely low activity of GSH-Px along with the increased activities of GST and DT diaphorase. AOX1 activity towards vanillin and (S)-RS-8359 was increased by selenium deficiency, and that corresponded to an increase of AOX1 protein level but not to a decreased AOX1 mRNA level. It has been documented that the assembly of the catalytically active holoenzvme forms of the molybdo-flavoenzyme family is very complex and is controlled through transcriptional and translational events by many gene products. In addition, selenium deficiency has been known to cause oxidative stress that leads to an increase of AOX1 activity. Furthermore, aldehyde oxidase homolog 1 (AOH1) with properties similar to AOX1 is present in rodent liver. All the reports suggest that the mechanisms by which selenium deficiency increases AOX1 activity are highly complicated and investigated from different points of view.

• 2009-02-01

著者

• FUJII Keiko

  Departments of Radiology, Osaka Rosai Hospital

• Fujii Keiko

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• SATO Jun

  Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University

• Tanaka Y

  Kyushu Univ. Fukuoka Jpn

• Sato Jun

  Department Of Neural Regulation Division Of Regulation Of Organ Function Research Institute Of Envir

• Itoh K

  Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G

• Itoh Kunio

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Adachi Mayuko

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Tanaka Y

  Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn

• Tanaka Yorihisa

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• SHOUJI Kanako

  Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University

• FUKIYA Kensuke

  Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University

• Shouji Kanako

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Fukiya Kensuke

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Tanaka Yorihisa

  Department Of Applied Chemistry National Defense Academy

• Sato Jun

  Department Of Applied Physics And Chemistry The University Of Electro-communications

• Sato Jun

  Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University

• Sato Jun

  Department Of Anesthesia Gunma Cancer Center

• Tanaka Yoshitaka

  Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University

• Itoh Kunio

  Department of Biopharmaceutics, Tohoku Pharmaceutical University

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