Substrate Selectivity of Monoamine Oxidase A, Monoamine Oxidase B, Diamine Oxidase, and Semicarbazide-Sensitive Amine Oxidase in COS-1 Expression Systems(Biochemistry)
スポンサーリンク
概要
- 論文の詳細を見る
The substrate selectivity of monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), diamine oxidase (DAO), and semicarbazide-sensitive amine oxidase (SSAO) was investigated in the absence of chemical inhibitors using the COS-1 cells expressed with respective amine oxidase. Serotonin (5-hydroxytryptamine), 1-methylhistamine, and histamine were preferentially oxidized by MAO-A, SSAO, and DAO, respectively, at a low substrate concentration. In contrast, benzylamine, tyramine, and β-phenylethylamine served as substrates for all of MAO-A, MAO-B, and SSAO. Each amine oxidase showed broad substrate selectivity at a high substrate concentration. The cross-inhibition was remarkable in MAO-A and MAO-B, especially in MAO-A, but not in SSAO and DAO. A study of the substrate selectivity of amine oxidases should include consideration of the effects of substrate concentration and specific chemical inhibitors.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
-
Tanaka Y
Kyushu Univ. Fukuoka Jpn
-
Ochiai Yoshinori
Deparetment of Gene Diagnositics and Theraputics, Resarch Institute, International Medical Center of
-
Ochiai Yoshinori
Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University
-
Itoh K
Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G
-
Itoh Kunio
Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University
-
Adachi Mayuko
Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University
-
Sakurai Eiichi
Department Of Pharmaceutics I Tohoku College Of Pharmacy
-
Sakurai Eiichi
Aomori University
-
Tanaka Y
Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn
-
Tanaka Yorihisa
Department Of Drug Metabolism And Pharmacokinetics Tohoku Pharmaceutical University
-
Ochiai Yuta
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
-
Sakurai E
Dep. Of Pharmacology Tohoku Univ. Graduate School Of Medicine
-
Tanaka Yorihisa
Department Of Applied Chemistry National Defense Academy
-
Sakurai Eiko
Department Of Pharmacology Tohoku University School Of Medicine
-
Tanaka Yoshitaka
Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University
-
Itoh Kunio
Department of Biopharmaceutics, Tohoku Pharmaceutical University
関連論文
- Effects of Selenium Deficiency on Aldehyde Oxidase 1 in Rats(Molecular and Cell Biology)
- Methamphetamine- and 3,4-Methylenedioxymethamphetamine-Induced Behavioral Changes in Histamine H_3-Receptor Knockout Mice
- Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli
- Mechanism of Resistance to Oxidative Stress in Doxorubicin Resistant Cells
- Separation of Caffeine from Supercritical Carbon Dioxide with a Zeolite Membrane
- Effect of Solute Adsorption Properties on Its Separation from Supercritical Carbon Dioxide with a Thin Porous Silica Membrane
- Evaluation of the Binding Characteristics of [5-^11C-methoxy]Donepezil in the Rat Brain for In Vivo Visualization of Acetylcholinesterase
- PJ-620 Unraveling Genetic Susceptibility by Constructing 14 Consomic Strains Derived from the Spontaneously Hypertensive Rat Strains(Genetics/Genetically engineered models/Gene therapy-4, The 71st Annual Scientific Meeting of the Japanese Circulation Soci
- Effect of Dietary cabbage Fermentation Extract and Young Barley Leaf Powder on Immune Function of Sprague-Dawley Rats
- Candesartan-Induced Gene Expression in Five Organs of Stroke-Prone Spontaneously Hypertensive Rats
- Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines
- Preparation of a Monoclonal Antibody Specific for 5-Methyl-2'-deoxycytidine and Its Application for the Detection of DNA Methylation Levels in Human Peripheral Blood Cells
- Comparison of Serum and Urinary Levels of Modified Nucleoside, 1-Methyladenosine, in Cancer Patients Using a Monoclonal Antibody-Based Inhibition ELISA
- Increased Expression of Queuosine Synthesizing Enzyme, tRNA-Guanine Transglycosylase, and Queuosine Levels in tRNA of Leukemic Cells
- Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
- Aerobic Oxidation of Thiols to Disulfides Catalyzed by Trichlorooxyvanadium
- Lysosomal Cysteine Protease, Cathepsin H, Is Targeted to Lysosomes by the Mannose 6-Phosphate-Independent System in Rat Hepatocytes
- Lysosomal Cystein Protease, Cathepsin B, Is Targeted to Lysosomes by the Mannose 6-Phosphate-Independent Pathway in Rat Hepatocytes: Site-Specific Phosphorylation in Oligosaccharides of the Proregion
- Stereoselective Pharmacokinetics of RS-8359,A Selective and Reversible Inhibitor of A-Type Monoamine Oxidase, in Rats, Mice, Dogs, and Monkeys
- Delayed Release of Prostaglandins from Arachidonic Acid and Kinetic Changes in Prostaglandin H Synthase Activity on the Induction of Prostaglandin H Synthase-2 after Lipopolysaccharide-Treatment of RAW264.7 Macrophage-Like Cells
- Quantitative determination of diol metabolites of CS-670, a new antiinflammatory agent, by capillary column gas chromatography-mass spectrometry
- Functional Analysis of Aldehyde Oxidase Using Expressed Chimeric Enzyme between Monkey and Rat(Molecular and Cell Biology)
- Properties of 130 kDa Subunit of Monkey Aldehyde Oxidase(Molecular and Cell Biology)
- Cloning, Expression, and Characterization of Male Cynomolgus Monkey Liver Aldehyde Oxidase(Biochemistry)
- Substrate Selectivity of Monoamine Oxidase A, Monoamine Oxidase B, Diamine Oxidase, and Semicarbazide-Sensitive Amine Oxidase in COS-1 Expression Systems(Biochemistry)
- Molecular Cloning and Characterization of Rat Semicarbazide-Sensitive Amine Oxidase(Biochemistry/Molecular Biology)
- Effect of Lipophilicity on in Vivo Iontophoretic Delivery. II. β-Blockers
- Iontophoretic Transdermal Delivery of Ketoprofen : Effect of Iontophoresis on Drug Transfer from Skin to Cutaneous Blood
- Phenotypic Conversion of SV-40-Immortalized Human Diploid Fibroblasts to Senescing Cells by Introduction of an Antisense Gene for SV40-T Antigen
- Epitaxial Solution Growth of ZnTe on ZnSe
- The Effect of Haloperidol on the Histaminergic Neuron System in the Rat Brain
- Blocking Histamine H_1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection
- THE DISPOSITION OF ENANTIOMERS. V. A METHOD FOR THE OPTICAL RESOLUTION OF CHLORPHENIRAMINE AND ITS STEREOSELECTIVE PHARMACOKINETICS
- EFFECT OF CONCANAVALIN A ON THE ASPIRIN CONCENTRATION AND DISTRIBUTION IN THE BRAIN AND PLASMA OF RATS
- ALTERATION OF HISTAMINE, SEROTONIN AND PRIMARY PROSTAGLANDIN IN CASE OF DIARRHEA INDUCED BY ENDOTOXIN AND GASTROINTESTINAL ABSORPTION OF DRUG
- The Effect of Eddy Current in the Feromagnetic Resonance of Spherical Specimens
- Relationship Between Effects of Alcohol on Psychomotor Performances and Blood Alcohol Concentrations
- Study of White-LED Using Amorphous Carbon Nitride Grown by RF-sputtering and ECR-plasma CVD
- Synthesis of grafted polysilsesquioxane by ring-opening polymerization of lactide and trimethylene carbonate
- The Effect of Skin Depth on Ferromagnetic Resonance in Spherical Ferrites
- Ferromagnetic Crystalline Anisotropy and Transition Temperature of Ti-Substituted Magnetite
- Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats
- ALTERATIONS OF CHOLECYSTOKININ-LIKE MATERIAL IN THE CASE OF DIARRHEA INDUCED BY VARIOUS CATHARTICS
- Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats
- Functional Analysis of Aldehyde Oxidase Using Expressed Chimeric Enzyme between Monkey and Rat
- Subcutaneous Panniculitis-Like T-Cell Lymphoma (SPTCL) with Hemophagocytosis (HPS)