Blocking Histamine H1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the role of histamine in mice with social isolation and repeated methamphetamine administration. Mice with social isolation and repeated methamphetamine administration showed significant disruption of prepulse inhibition as compared to both the socially-housed mice and isolation-housing mice. Furthermore, social isolation and repeated methamphetamine administration caused significant learning and mnemonic dysfunctions. Treatment with clozapine improved learning and mnemonic ability in all of the tasks. Pyrilamine treatment ameliorated performance in all the tests examined except for the passive avoidance test. Thioperamide, however, did not change the learning and mnemonic ability. Donepezil, an acetylcholinesterase inhibitor, reversed the learning and mnemonic dysfunction in all four tasks. The present study has shown that blockade of histamine H1 receptor improved the learning and mnemonic ability in mice, raising the possibility that treatment with clozapine or pyrilamine may improve learning and mnemonic performance in certain patients with psychiatric diseases such as schizophrenic patients with cognitive dysfunction.
著者
-
Kato Motohisa
Department Of Organic And Polymeric Materials Tokyo Institute Of Technology
-
Okuda Tomohiro
Department Of Anesthesiology National Defense Medical College
-
Mobarakeh Jalal
Department Of Pharmacology Tohoku University School Of Medicine
-
Jia Feiyong
Department Of Pharmacology Tohoku University School Of Medicine
-
Xu Ajing
Department Of Pharmacology Xinhua Hospital School Of Medicine Shanghai Jiaotong University
-
TAKAHASHI Kazuhiro
Department of Analytical Medical Technology, Tohoku University School of Health Sciences
-
DAI Hongmei
Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
-
OKAMURA Nobuyuki
Department of Cardiovascular Surgery, Showa General Hospital
-
Sakurai Eiko
Department of Pharmacology I, Tohoku University School of Medicine
-
Yanai Kazuhiko
Department of Pharmacology I, Tohoku University School of Medicine
-
Mobarakeh Jalal
Department of Pharmacology, Tohoku University School of Medicine, Japan
-
Yanai Kazuhiko
Department of Pharmacology, Tohoku University School of Medicine, Japan
-
Sakurai Eiko
Department of Pharmacology, Tohoku University School of Medicine, Japan
-
Okuda Tomohiro
Department of Pharmacology, Tohoku University School of Medicine, Japan
-
Okamura Nobuyuki
Department of Pharmacology, Tohoku University School of Medicine, Japan
-
Xu Ajing
Department of Pharmacology, Tohoku University School of Medicine, Japan
-
Takahashi Kazuhiro
Department of Endocrinology and Applied Medical Science, Tohoku University School of Medicine, Japan
関連論文
- Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, inhibits IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells
- Binding and safety profile of novel benzoxazole derivative for in vivo imaging of amyloid deposits in Alzheimer's disease
- Lithium therapy and cerebrospinal fluid biomarker levels in Alzheimer's disease
- Body surface area is an independent factor contributing to the effects of lamivudine treatment
- Management of late atrial tachyarrhythmia long after Fontan operation
- PJ-773 Chronic Kidney Disease in Adult Congenital Heart Disease(PJ130,Congenital Heart Disease/Kawasaki's Disease (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-700 Noncontact Mapping and Catheter Ablation of Atrial Tachycardia in Patients Late after Intra-cardiac Repair for Complex Congenital Heart Disease(PJ118,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 6 (A),Poster Session (Japanese),The 73rd Annual
- 2 Management of "Anticipated" Admissions in Adult Congenital Heart Disease Clinic(Patient Menagement System for Adult Congenital Heart Disease,Symposium 19 (SY-19) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-369 Novel Mapping Technique with Simultaneous Use of Electroanatomical Mapping System and Noncontact Mapping System for Atrial Tachycardia after Open-heart Surgery(Arrhythmia, therapy(09)(A),Poster Session(English),The 72nd Annual Scientific Meeting of
- Methamphetamine- and 3,4-Methylenedioxymethamphetamine-Induced Behavioral Changes in Histamine H_3-Receptor Knockout Mice
- Immunohistochemistry of a Proliferation Marker Ki67/MIB1 in Adrenocortical Carcinomas : Ki67/MIB1 Labeling Index Is a Predictor for Recurrence of Adrenocortical Carcinomas
- Germ Cell-Specific Expression of Microphthalmia-Associated Transcription Factor mRNA in Mouse Testis
- Decreased Expression of Adrenomedullin during Adipocyte-Differentiation of 3T3-L1 Cells
- Molecular Cloning of cDNA Encoding a Novel Microphthalmia-Associated Transcription Factor Isoform with a Distinct Amino-Terminus
- Role of Neurofibromin in Modulation of Expression of the Tyroshinase-Related Protein 2 Gene
- Differential Tissue-Specific Expression of Neurofibromin Isoform mRNAs in Rat^1
- Evidence for the Presence of Two Amino-Terminal Isoforms of Neurofibromin, a Gene Product Responsible for Neurofibromatosis Type 1
- Rpp16 and Rpp17, from a Common Origin, have Different Protein Characteristics but Both Genes are Predominantly Expressed in Rice Phloem Tissues
- Electrophysiological Properties and Radiofrequency Catheter Ablation for Arrhythmias in Adults Associated with Congenital Heart Disease(Diagnosis and Management of Arrhythmias in Adults with Congenital Heart, The 69th Annual Scientific Meeting of the Japa
- FRS-013 Long-term Outcome of Catheter Ablation for Ventricular Tachycardia in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy(Clinical Arrhythmia-2 (A) FRS3,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japa
- Methicillin Resistant Staphylococcus Aureus Infection of Implantable Antiarrhythmic Device (Arrhythmia, Non-pharmacological Therapy 9 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Electrophysiological Properties and Catheter Ablation for Cavotricuspid Isthmus-independent Macroreentrant Atrial Tachycardia(Arrhythmia, Non-pharmacological Therapy 8 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Radiofrequency Catheter Ablation of Atrial Fibrillation Targeting for Arrhythmogenic Substrate in Right Atrium(Arrhythmia, Non-pharmacological Therapy 10 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Can oral prostacyclin improve the pulmonary circulation in Fontan candidates?
- Importance of luxury flow for critically ill patients receiving a left ventricular assist system
- Elevated Plasma Immunoreactive Neuropeptide Y Concentrations and Its Increased Urinary Excretion in Patients with Advanced Diabetic Nephropathy
- Evaluation of the Binding Characteristics of [5-^11C-methoxy]Donepezil in the Rat Brain for In Vivo Visualization of Acetylcholinesterase
- Preparation and Electrochemical Properties of the Green Ytterbium (III) and Lutetium (III) Sandwich Complexes of Octabutoxy-Substituted Phthalocyanine
- Acral pigmentation caused by a vitamin B_ deficiency
- PE-073 Utility of brain natriuretic peptide (BNP) in prediction of stable coronary ischemia(Angina Pectoris, Clinical 1 (IHD) : PE13)(Poster Session (English))
- Comparison of cilostazol and ticlopidine for prevention of restenosis and thrombosis after coronary stent implantation
- Expression of Endothelin-1 and Adrenomedullin Was Not Altered by Leptin or Resistin in Bovine Brain Microvascular Endothelial Cells
- Expression of three vasoactive peptides, urotensin-II, adrenomedullin, and endothelin-1, in a human renal cell carcinoma cell line, VMRC-RCW
- Effect of Regional Tracer Delay on CBF in Healthy Subjects Measured with Dynamic Susceptibility Contrast-Enhanced MRI : Comparison with ^O-PET
- PET measurements of CBF, OEF, and CMRO_2 without arterial sampling in hyperacute ischemic stroke : Method and error analysis
- Use of reference tissue models for quantification of histamine H_1 receptors in human brain by using positron emission tomography and [^C]doxepin
- Copper(II) Compounds Extended by 5-Carboxysalicylaldehyde and Its Schiff Bases: Interplay of Two Metal-Binding Sites and Intermolecular Stacking Contributing to Their Network and Bulk Structures
- Synthesis and Characterization of Triple-decker Sandwich Dinuclear La(III)and Lu(III)Complexes of 2, 3, 9, 10, 16, 17, 23, 24-Octabutoxyphthalocyanine
- Possible Implications of the Induction of Human Heme Oxygenase-1 by Nitric Oxide Donors^1
- Preparation, Characterization, and Electrochemical Properties of Tris(2,3,9,10,16,17,23,24-octabutoxyphthalocyaninato)diytterbium(III) and -didysprosium(III)
- Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
- 2-7 Brain Histamine H1 Receptor Occupancy of Orally-administered Antihistamines, Measured by PET with 11C-doxepin(Proceedings of the 56th Meeting of Japan Society of Physiological Anthropology)
- Geriatric Medicine, Japanese Alzheimer's Disease Neuroimaging Initiative and Biomarker Development
- バナジウム・モリブデン酸化物のリチウム挿入挙動
- Acromegaly with Normal IGF-1 Levels Probably due to Poorly Controlled Diabetes Mellitus
- Children's toxicology from bench to bed - Drug-induced Renal Injury (1) : The toxic effects of ARB/ACEI on fetal kidney development
- The Effect of Haloperidol on the Histaminergic Neuron System in the Rat Brain
- HDI-30 SUB-NANO-NEWTON DYNAMIC SHEAR FORCE MEASUREMENT FOR FIBER WOBBLING METHOD
- Blocking Histamine H_1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection
- Recent Advances in Molecular Pharmacology of the Histamine Systems : Roles of C-terminal Tails of Histamine Receptors
- Recent Advances in Molecular Pharmacology of the Histamine System : Preface
- Normal proliferative responses of peripheral blood mononuclear cells to streptococcal preparation OK-432 in patients with pustulosis palmaris et plantaris constitute a distinct feature from the reduced responses observed in those with psoriasis vulgaris,
- Studies on Functional Roles of the Histaminergic Neuron System by Using Pharmacological Agents, Knockout Mice and Positron Emission Tomography
- Cutaneous late phase reaction in adult atopic dermatitis patients with high serum IgE antibody to Dermatophagoides farinae : correlation with IL-5 production by allergen-stimulated peripheral blood mononuclear cells
- Lichen amyloidosis induced on the upper back by long-term friction with a nylon towel
- Epidural abscess as a side effect of an immunosuppressive therapy treatment for bullous pemphigoid
- Growth and Disappearance of Nanobubbles during the Foaming of Polycarbonate
- Relationship Between Effects of Alcohol on Psychomotor Performances and Blood Alcohol Concentrations
- Mechanisms of Chloramine and Cyanogen Chloride Formation from Glycine (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- Blocking Histamine H1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection
- Propofol injection pain is not alleviated by pretreatment with flurbiprofen axetil, a prodrug of a nonsteroidal antiinflammatory drug
- Decreased expression of adrenomedullin 2/intermedin in the kidney of hypertension or renal failure ; Possible involvement in chronic kidney disease
- Binding Characteristics of a Histamine H3-Receptor Antagonist, [3H]S-Methylthioperamide: Comparison with [3H](R)α-Methylhistamine Binding to Rat Tissues
- Multiple vascular eccrine spiradenomas : A case report and published work review of multiple eccrine spiradenomas
- Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats
- The QT Intervals in Infancy and Time for Infantile ECG Screening for Long QT Syndrome
- Translational Medicine in Fish-derived Peptides : From Fish Endocrinology to Human Physiology and Diseases
- On the Phase Transition of the Spin-One Ising System with the Biquadratic Interaction
- Green Function Approaches to the Heisenberg Ferromagnet with Biquadratic Interactions
- Dynamics of the Ising Model with the Bilinear and Biquadratic Interaction
- Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats
- Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese : the Ohasama study
- A modified method of 3D-SSP analysis for amyloid PET imaging using [^C]BF-227
- ACTH response to desmopressin in a patient with acromegaly ; Expression of corticotropin-releasing factor, urocortins and vasopressin V1b receptor in GH-producing pituitary adenoma
- Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion
- Atypically Located Pericardial Cyst in a Patient Who Underwent Off-pump Myocardial Revascularization
- Atypically Located Pericardial Cyst in a Patient Who Underwent Off-Pump Myocardial Revascularization
- Atypically Located Pericardial Cyst in a Patient Who Underwent Off-Pump Myocardial Revascularization
- Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior
- An inadequate dose of ribavirin is related to virological relapse by chronic hepatitis C patients treated with pegylated interferon alpha-2b and ribavirin
- In Situ Hybridization Method Reveals (Pro)renin Receptor Expressing Cells in the Pituitary Gland of Rats: Correlation with Anterior Pituitary Hormones
- Effects of Inhibitors of Protein Kinase C on the Release and Synthesis of Histamine in Rat Basophilic Leukemia Cells (2H3).
- Reaction of hydroxide ion with electron acceptors in dimethyl sulfoxide.
- Synthesis and properties of novel type binuclear copper(II) complexes whose coordination units are linked by a flexible polyatomic chain.
- Crystal Structure of the Gold(III) Complex, Trichloro (dibenzyl sulfide) golo(III).
- Crystal structures and characterization of cobalt(II), manganese(II), and zinc(II) complexes of 2-(bis-(2-benzimidazolylmethyl)amino)ethanol.
- Pegylated interferon α-2b plus ribavirin for Japanese chronic hepatitis C patients with normal alanine aminotransferase
- Germ Cell-Specific Expression of Microphthalmia-Associated Transcription Factor mRNA in Mouse Testis
- Platelet Transfusion Improves Liver Function in Patients with Chronic Liver Disease and Cirrhosis
- Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : the Ohasama study
- Circumscribed palmar or plantar hypokeratosis : Two cases and a review of published work
- Role of Neurofibromin in Modulation of Expression of the Tyrosinase-Related Protein 2 Gene.